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Ploidy dynamics increase the risk of liver cancer initiation

Author

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  • Miryam Müller

    (Cancer Research UK Beatson Institute)

  • Stephanie May

    (Cancer Research UK Beatson Institute)

  • Thomas G. Bird

    (Cancer Research UK Beatson Institute
    University of Edinburgh)

Abstract

Liver cancer typically arises after years of inflammatory insults to hepatocytes. These cells can change their ploidy state during health and disease. Whilst polyploidy may offer some protection, new research shows it may also promote the formation of liver tumours.

Suggested Citation

  • Miryam Müller & Stephanie May & Thomas G. Bird, 2021. "Ploidy dynamics increase the risk of liver cancer initiation," Nature Communications, Nature, vol. 12(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21897-8
    DOI: 10.1038/s41467-021-21897-8
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