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Hyocholic acid species as novel biomarkers for metabolic disorders

Author

Listed:
  • Xiaojiao Zheng

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Tianlu Chen

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Aihua Zhao

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Zhangchi Ning

    (Hong Kong Baptist University
    China Academy of Chinese Medical Sciences)

  • Junliang Kuang

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Shouli Wang

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Yijun You

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Yuqian Bao

    (Shanghai Diabetes Institute)

  • Xiaojing Ma

    (Shanghai Diabetes Institute)

  • Haoyong Yu

    (Shanghai Diabetes Institute)

  • Jian Zhou

    (Shanghai Diabetes Institute)

  • Miao Jiang

    (China Academy of Chinese Medical Sciences)

  • Mengci Li

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Jieyi Wang

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Xiaohui Ma

    (Tasly Pharmaceutical Co. Ltd)

  • Shuiping Zhou

    (Tasly Pharmaceutical Co. Ltd)

  • Yitao Li

    (Hong Kong Baptist University)

  • Kun Ge

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Cynthia Rajani

    (University of Hawaii Cancer Center)

  • Guoxiang Xie

    (University of Hawaii Cancer Center)

  • Cheng Hu

    (Shanghai Diabetes Institute)

  • Yike Guo

    (Hong Kong Baptist University)

  • Aiping Lu

    (Hong Kong Baptist University)

  • Weiping Jia

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
    Shanghai Diabetes Institute)

  • Wei Jia

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
    Hong Kong Baptist University
    University of Hawaii Cancer Center)

Abstract

Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict the development of metabolic disorders. We find in the first cohort (n = 1107) that both obesity and diabetes are associated with lower serum concentrations of HCA species. A separate cohort study (n = 91) validates this finding and further reveals that individuals with pre-diabetes are associated with lower levels of HCA species in feces. Serum HCA levels increase in the patients after gastric bypass surgery (n = 38) and can predict the remission of diabetes two years after surgery. The results are replicated in two independent, prospective cohorts (n = 132 and n = 207), where serum HCA species are found to be strong predictors for metabolic disorders in 5 and 10 years, respectively. These findings underscore the association of HCA species with diabetes, and demonstrate the feasibility of using HCA profiles to assess the future risk of developing metabolic abnormalities.

Suggested Citation

  • Xiaojiao Zheng & Tianlu Chen & Aihua Zhao & Zhangchi Ning & Junliang Kuang & Shouli Wang & Yijun You & Yuqian Bao & Xiaojing Ma & Haoyong Yu & Jian Zhou & Miao Jiang & Mengci Li & Jieyi Wang & Xiaohui, 2021. "Hyocholic acid species as novel biomarkers for metabolic disorders," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21744-w
    DOI: 10.1038/s41467-021-21744-w
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    Cited by:

    1. Marjolein Heddes & Baraa Altaha & Yunhui Niu & Sandra Reitmeier & Karin Kleigrewe & Dirk Haller & Silke Kiessling, 2022. "The intestinal clock drives the microbiome to maintain gastrointestinal homeostasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Jing Zhong & Xiaofang He & Xinxin Gao & Qiaohong Liu & Yu Zhao & Ying Hong & Weize Zhu & Juan Yan & Yifan Li & Yan Li & Ningning Zheng & Yiyang Bao & Hao Wang & Junli Ma & Wenjin Huang & Zekun Liu & Y, 2023. "Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Noëmie Daniel & Renato Tadeu Nachbar & Thi Thu Trang Tran & Adia Ouellette & Thibault Vincent Varin & Aurélie Cotillard & Laurent Quinquis & Andréanne Gagné & Philippe St-Pierre & Jocelyn Trottier & B, 2022. "Gut microbiota and fermentation-derived branched chain hydroxy acids mediate health benefits of yogurt consumption in obese mice," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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