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The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase

Author

Listed:
  • Ryota Akiyama

    (Kobe University)

  • Bunta Watanabe

    (Kyoto University)

  • Masaru Nakayasu

    (Kobe University
    Kyoto University)

  • Hyoung Jae Lee

    (Kobe University)

  • Junpei Kato

    (Kobe University)

  • Naoyuki Umemoto

    (RIKEN Center for Sustainable Resource Science)

  • Toshiya Muranaka

    (Osaka University)

  • Kazuki Saito

    (RIKEN Center for Sustainable Resource Science
    Chiba University)

  • Yukihiro Sugimoto

    (Kobe University)

  • Masaharu Mizutani

    (Kobe University)

Abstract

Potato (Solanum tuberosum), a worldwide major food crop, produces the toxic, bitter tasting solanidane glycoalkaloids α-solanine and α-chaconine. Controlling levels of glycoalkaloids is an important focus on potato breeding. Tomato (Solanum lycopersicum) contains a bitter spirosolane glycoalkaloid, α-tomatine. These glycoalkaloids are biosynthesized from cholesterol via a partly common pathway, although the mechanisms giving rise to the structural differences between solanidane and spirosolane remained elusive. Here we identify a 2-oxoglutarate dependent dioxygenase, designated as DPS (Dioxygenase for Potato Solanidane synthesis), that is a key enzyme for solanidane glycoalkaloid biosynthesis in potato. DPS catalyzes the ring-rearrangement from spirosolane to solanidane via C-16 hydroxylation. Evolutionary divergence of spirosolane-metabolizing dioxygenases contributes to the emergence of toxic solanidane glycoalkaloids in potato and the chemical diversity in Solanaceae.

Suggested Citation

  • Ryota Akiyama & Bunta Watanabe & Masaru Nakayasu & Hyoung Jae Lee & Junpei Kato & Naoyuki Umemoto & Toshiya Muranaka & Kazuki Saito & Yukihiro Sugimoto & Masaharu Mizutani, 2021. "The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21546-0
    DOI: 10.1038/s41467-021-21546-0
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    Cited by:

    1. Wei Sun & Qinggang Yin & Huihua Wan & Ranran Gao & Chao Xiong & Chong Xie & Xiangxiao Meng & Yaolei Mi & Xiaotong Wang & Caixia Wang & Weiqiang Chen & Ziyan Xie & Zheyong Xue & Hui Yao & Peng Sun & Xu, 2023. "Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Yongming Liu & Gengxin Xie & Qichang Yang & Maozhi Ren, 2021. "Biotechnological development of plants for space agriculture," Nature Communications, Nature, vol. 12(1), pages 1-3, December.

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