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The prevalence of antibodies to SARS-CoV-2 among blood donors in China

Author

Listed:
  • Le Chang

    (Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences
    Beijing Hospital)

  • Wangheng Hou

    (Xiamen University
    Xiamen University)

  • Lei Zhao

    (Wuhan Blood Center
    Institute of Blood Transfusion of Hubei Province)

  • Yali Zhang

    (Xiamen University
    Xiamen University)

  • Yanbin Wang

    (Hebei Province Blood Center)

  • Linfeng Wu

    (Shenzhen Blood Center)

  • Tingting Xu

    (Wuhan Blood Center
    Institute of Blood Transfusion of Hubei Province)

  • Lilin Wang

    (Shenzhen Blood Center)

  • Juan Wang

    (Xiamen University
    Xiamen University)

  • Jian Ma

    (Xiamen University
    Xiamen University)

  • Lan Wang

    (Wuhan Blood Center)

  • Junpeng Zhao

    (Shenzhen Blood Center)

  • Jing Xu

    (Wuhan Blood Center)

  • Juan Dong

    (Wuhan Blood Center
    Institute of Blood Transfusion of Hubei Province)

  • Ying Yan

    (Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences
    Beijing Hospital)

  • Ru Yang

    (Wuhan Blood Center)

  • Yu Li

    (Wuhan Blood Center
    Institute of Blood Transfusion of Hubei Province)

  • Fei Guo

    (Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences
    Beijing Hospital)

  • Wenjuan Cheng

    (Wuhan Blood Center
    Institute of Blood Transfusion of Hubei Province)

  • Yingying Su

    (Xiamen University
    Xiamen University)

  • Jinfeng Zeng

    (Shenzhen Blood Center)

  • Wei Han

    (Hebei Province Blood Center)

  • Tong Cheng

    (Xiamen University
    Xiamen University)

  • Jun Zhang

    (Xiamen University
    Xiamen University)

  • Quan Yuan

    (Xiamen University
    Xiamen University)

  • Ningshao Xia

    (Xiamen University
    Xiamen University)

  • Lunan Wang

    (Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences
    Beijing Hospital
    Peking Union Medical College, Chinese Academy of Medical Sciences)

Abstract

In this study, we investigate the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China. From January to April 2020, 38,144 healthy blood donors in the three cities were tested for total antibody against SARS-CoV-2 followed by pseudotype SARS-CoV-2 neutralization tests, IgG, and IgM antibody testing. Finally, a total of 398 donors were confirmed positive. The age- and sex-standardized SARS-CoV-2 seroprevalence among 18–60 year-old adults (18–65 year-old in Shenzhen) was 2.66% (95% CI: 2.24%–3.07%) in Wuhan, 0.033% (95% CI: 0.0029%–0.267%) in Shenzhen, and 0.0028% (95% CI: 0.0001%–0.158%) in Shijiazhuang, respectively. Female sex and older-age were identified to be independent risk factors for SARS-CoV-2 seropositivity among blood donors in Wuhan. As most of the population of China remained uninfected during the early wave of the COVID-19 pandemic, effective public health measures are still certainly required to block viral spread before a vaccine is widely available.

Suggested Citation

  • Le Chang & Wangheng Hou & Lei Zhao & Yali Zhang & Yanbin Wang & Linfeng Wu & Tingting Xu & Lilin Wang & Juan Wang & Jian Ma & Lan Wang & Junpeng Zhao & Jing Xu & Juan Dong & Ying Yan & Ru Yang & Yu Li, 2021. "The prevalence of antibodies to SARS-CoV-2 among blood donors in China," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21503-x
    DOI: 10.1038/s41467-021-21503-x
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