Author
Listed:
- Cheng-Tao Jiang
(Guangzhou International Campus)
- Kai-Ge Chen
(University of Science and Technology of China)
- An Liu
(University of Science and Technology of China)
- Hua Huang
(Guangzhou International Campus)
- Ya-Nan Fan
(Guangzhou International Campus)
- Dong-Kun Zhao
(Guangzhou International Campus)
- Qian-Ni Ye
(Guangzhou International Campus)
- Hou-Bing Zhang
(Guangzhou International Campus)
- Cong-Fei Xu
(Guangzhou International Campus
Shenzhen Bay Laboratory)
- Song Shen
(Guangzhou International Campus
South China University of Technology
South China University of Technology)
- Meng-Hua Xiong
(Guangzhou International Campus)
- Jin-Zhi Du
(Guangzhou International Campus)
- Xian-Zhu Yang
(Guangzhou International Campus
South China University of Technology)
- Jun Wang
(Guangzhou International Campus
South China University of Technology
Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
South China University of Technology)
Abstract
Modulating effector immune cells via monoclonal antibodies (mAbs) and facilitating the co-engagement of T cells and tumor cells via chimeric antigen receptor- T cells or bispecific T cell-engaging antibodies are two typical cancer immunotherapy approaches. We speculated that immobilizing two types of mAbs against effector cells and tumor cells on a single nanoparticle could integrate the functions of these two approaches, as the engineered formulation (immunomodulating nano-adaptor, imNA) could potentially associate with both cells and bridge them together like an ‘adaptor’ while maintaining the immunomodulatory properties of the parental mAbs. However, existing mAbs-immobilization strategies mainly rely on a chemical reaction, a process that is rough and difficult to control. Here, we build up a versatile antibody immobilization platform by conjugating anti-IgG (Fc specific) antibody (αFc) onto the nanoparticle surface (αFc-NP), and confirm that αFc-NP could conveniently and efficiently immobilize two types of mAbs through Fc-specific noncovalent interactions to form imNAs. Finally, we validate the superiority of imNAs over the mixture of parental mAbs in T cell-, natural killer cell- and macrophage-mediated antitumor immune responses in multiple murine tumor models.
Suggested Citation
Cheng-Tao Jiang & Kai-Ge Chen & An Liu & Hua Huang & Ya-Nan Fan & Dong-Kun Zhao & Qian-Ni Ye & Hou-Bing Zhang & Cong-Fei Xu & Song Shen & Meng-Hua Xiong & Jin-Zhi Du & Xian-Zhu Yang & Jun Wang, 2021.
"Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy,"
Nature Communications, Nature, vol. 12(1), pages 1-14, December.
Handle:
RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21497-6
DOI: 10.1038/s41467-021-21497-6
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Citations
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Cited by:
- Qian-Ni Ye & Long Zhu & Jie Liang & Dong-Kun Zhao & Tai-Yu Tian & Ya-Nan Fan & Si-Yi Ye & Hua Liu & Xiao-Yi Huang & Zhi-Ting Cao & Song Shen & Jun Wang, 2024.
"Orchestrating NK and T cells via tri-specific nano-antibodies for synergistic antitumor immunity,"
Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Yue Wang & Shi-Kun Zhou & Yan Wang & Zi-Dong Lu & Yue Zhang & Cong-Fei Xu & Jun Wang, 2023.
"Engineering tumor-specific gene nanomedicine to recruit and activate T cells for enhanced immunotherapy,"
Nature Communications, Nature, vol. 14(1), pages 1-18, December.
- Ziyang Cao & Dongdong Li & Liang Zhao & Mengting Liu & Pengyue Ma & Yingli Luo & Xianzhu Yang, 2022.
"Bioorthogonal in situ assembly of nanomedicines as drug depots for extracellular drug delivery,"
Nature Communications, Nature, vol. 13(1), pages 1-12, December.
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