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Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition

Author

Listed:
  • Bingfang Zhang

    (Chinese Academy of Sciences
    Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Lei Wang

    (University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Aisheng Zhan

    (Chinese Academy of Sciences
    Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Min Wang

    (Chinese Academy of Sciences)

  • Lanxiang Tian

    (Chinese Academy of Sciences
    Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Weixiang Guo

    (University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Yongxin Pan

    (Chinese Academy of Sciences
    Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

Abstract

Adult hippocampal neurogenesis contributes to learning and memory, and is sensitive to a variety of environmental stimuli. Exposure to a hypomagnetic field (HMF) influences the cognitive processes of various animals, from insects to human beings. However, whether HMF exposure affect adult hippocampal neurogenesis and hippocampus-dependent cognitions is still an enigma. Here, we showed that male C57BL/6 J mice exposed to HMF by means of near elimination of the geomagnetic field (GMF) exhibit significant impairments of adult hippocampal neurogenesis and hippocampus-dependent learning, which is strongly correlated with a reduction in the content of reactive oxygen species (ROS). However, these deficits seen in HMF-exposed mice could be rescued either by elevating ROS levels through pharmacological inhibition of ROS removal or by returning them back to GMF. Therefore, our results suggest that GMF plays an important role in adult hippocampal neurogenesis through maintaining appropriate endogenous ROS levels.

Suggested Citation

  • Bingfang Zhang & Lei Wang & Aisheng Zhan & Min Wang & Lanxiang Tian & Weixiang Guo & Yongxin Pan, 2021. "Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21468-x
    DOI: 10.1038/s41467-021-21468-x
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