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A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy

Author

Listed:
  • Junrong Li

    (The University of Queensland)

  • Alain Wuethrich

    (The University of Queensland)

  • Abu A. I. Sina

    (The University of Queensland)

  • Han-Hao Cheng

    (The University of Queensland)

  • Yuling Wang

    (Macquarie University)

  • Andreas Behren

    (La Trobe University
    University of Melbourne)

  • Paul N. Mainwaring

    (The University of Queensland)

  • Matt Trau

    (The University of Queensland
    The University of Queensland)

Abstract

The introduction of immune checkpoint inhibitors has demonstrated significant improvements in survival for subsets of cancer patients. However, they carry significant and sometimes life-threatening toxicities. Prompt prediction and monitoring of immune toxicities have the potential to maximise the benefits of immune checkpoint therapy. Herein, we develop a digital nanopillar SERS platform that achieves real-time single cytokine counting and enables dynamic tracking of immune toxicities in cancer patients receiving immune checkpoint inhibitor treatment - broader applications are anticipated in other disease indications. By analysing four prospective cytokine biomarkers that initiate inflammatory responses, the digital nanopillar SERS assay achieves both highly specific and highly sensitive cytokine detection down to attomolar level. Significantly, we report the capability of the assay to longitudinally monitor 10 melanoma patients during immune inhibitor blockade treatment. Here, we show that elevated cytokine concentrations predict for higher risk of developing severe immune toxicities in our pilot cohort of patients.

Suggested Citation

  • Junrong Li & Alain Wuethrich & Abu A. I. Sina & Han-Hao Cheng & Yuling Wang & Andreas Behren & Paul N. Mainwaring & Matt Trau, 2021. "A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21431-w
    DOI: 10.1038/s41467-021-21431-w
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    Cited by:

    1. Jacopo Cardellini & Caterina Dallari & Ilaria Santis & Lorenzo Riccio & Costanza Ceni & Amelia Morrone & Martino Calamai & Francesco Saverio Pavone & Caterina Credi & Costanza Montis & Debora Berti, 2024. "Hybrid lipid-AuNP clusters as highly efficient SERS substrates for biomedical applications," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Tae Yeon Kim & Jee Won Mok & Sang Hoon Hong & Sang Hoon Jeong & Hyunsik Choi & Sangbaie Shin & Choun-Ki Joo & Sei Kwang Hahn, 2022. "Wireless theranostic smart contact lens for monitoring and control of intraocular pressure in glaucoma," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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