IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-21413-y.html
   My bibliography  Save this article

Implication of TIGIT+ human memory B cells in immune regulation

Author

Listed:
  • Md Mahmudul Hasan

    (Mayo Clinic)

  • Sumi Sukumaran Nair

    (Mayo Clinic)

  • Jacqueline G. O’Leary

    (Baylor University Medical Center)

  • LuAnn Thompson-Snipes

    (Baylor University Medical Center)

  • Verah Nyarige

    (Mayo Clinic)

  • Junwen Wang

    (Mayo Clinic)

  • Walter Park

    (Mayo Clinic)

  • Mark Stegall

    (Mayo Clinic)

  • Raymond Heilman

    (Mayo Clinic)

  • Goran B. Klintmalm

    (Baylor University Medical Center)

  • HyeMee Joo

    (Mayo Clinic)

  • SangKon Oh

    (Mayo Clinic)

Abstract

Regulatory B cells (Bregs) contribute to immune regulation. However, the mechanisms of action of Bregs remain elusive. Here, we report that T cell immunoreceptor with Ig and ITIM domains (TIGIT) expressed on human memory B cells especially CD19+CD24hiCD27+CD39hiIgD−IgM+CD1c+ B cells is essential for effective immune regulation. Mechanistically, TIGIT on memory B cells controls immune response by directly acting on T cells and by arresting proinflammatory function of dendritic cells, resulting in the suppression of Th1, Th2, Th17, and CXCR5+ICOS+ T cell response while promoting immune regulatory function of T cells. TIGIT+ memory B cells are also superior to other B cells at expressing additional inhibitory molecules, including IL-10, TGFβ1, granzyme B, PD-L1, CD39/CD73, and TIM-1. Lack or decrease of TIGIT+ memory B cells is associated with increased donor-specific antibody and TFH response, and decreased Treg response in renal and liver allograft patients. Therefore, TIGIT+ human memory B cells play critical roles in immune regulation.

Suggested Citation

  • Md Mahmudul Hasan & Sumi Sukumaran Nair & Jacqueline G. O’Leary & LuAnn Thompson-Snipes & Verah Nyarige & Junwen Wang & Walter Park & Mark Stegall & Raymond Heilman & Goran B. Klintmalm & HyeMee Joo &, 2021. "Implication of TIGIT+ human memory B cells in immune regulation," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21413-y
    DOI: 10.1038/s41467-021-21413-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-21413-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-21413-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. S. Shankar & J. Stolp & S. C. Juvet & J. Beckett & P. S. Macklin & F. Issa & J. Hester & K. J. Wood, 2022. "Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21413-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.