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SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

Author

Listed:
  • Nicolas Huot

    (Unité HIV, Inflammation et Persistance)

  • Philippe Rascle

    (Unité HIV, Inflammation et Persistance
    Université Paris Diderot, Sorbonne Paris Cité)

  • Caroline Petitdemange

    (Unité HIV, Inflammation et Persistance)

  • Vanessa Contreras

    (IDMIT Department, IBFJ)

  • Christina M. Stürzel

    (Ulm University Medical Center)

  • Eduard Baquero

    (Unité de Virologie Structurale)

  • Justin L. Harper

    (Emory University)

  • Caroline Passaes

    (Unité HIV, Inflammation et Persistance)

  • Rachel Legendre

    (Institut Pasteur)

  • Hugo Varet

    (Institut Pasteur)

  • Yoann Madec

    (Institut Pasteur; Epidemiology of Emerging Diseases Unit)

  • Ulrike Sauermann

    (Deutsches Primatenzentrum - Leibniz Institut für Primatenforschung)

  • Christiane Stahl-Hennig

    (Deutsches Primatenzentrum - Leibniz Institut für Primatenforschung)

  • Jacob Nattermann

    (Universitätsklinikum Bonn, Germany; German Center for Infection Research (DZIF))

  • Asier Saez-Cirion

    (Unité HIV, Inflammation et Persistance)

  • Roger Grand

    (IDMIT Department, IBFJ)

  • R. Keith Reeves

    (Harvard Medical School)

  • Mirko Paiardini

    (Emory University
    Emory University School of Medicine)

  • Frank Kirchhoff

    (Ulm University Medical Center)

  • Beatrice Jacquelin

    (Unité HIV, Inflammation et Persistance)

  • Michaela Müller-Trutwin

    (Unité HIV, Inflammation et Persistance)

Abstract

Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of SIVagm infection in secondary lymphoid tissues. We demonstrate that SIVagm infection induces the expansion of terminally differentiated NKG2alow NK cells in secondary lymphoid organs displaying an adaptive transcriptional profile and increased MHC-E-restricted cytotoxicity in response to SIV Env peptides while expressing little IFN-γ. Such NK cell differentiation was lacking in SIVmac-infected macaques. Adaptive NK cells displayed no increased NKG2C expression. This study reveals a previously unknown profile of NK cell adaptation to a viral infection, thus accelerating strategies toward NK-cell directed therapies and viral control in tissues.

Suggested Citation

  • Nicolas Huot & Philippe Rascle & Caroline Petitdemange & Vanessa Contreras & Christina M. Stürzel & Eduard Baquero & Justin L. Harper & Caroline Passaes & Rachel Legendre & Hugo Varet & Yoann Madec & , 2021. "SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21402-1
    DOI: 10.1038/s41467-021-21402-1
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    Cited by:

    1. Maria Pino & Amélie Pagliuzza & M. Betina Pampena & Claire Deleage & Elise G. Viox & Kevin Nguyen & Inbo Shim & Adam Zhang & Justin L. Harper & Sadia Samer & Colin T. King & Barbara Cervasi & Kiran P., 2022. "Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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