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Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes

Author

Listed:
  • Adam B. Weiner

    (Northwestern University Feinberg School of Medicine)

  • Thiago Vidotto

    (Johns Hopkins University School of Medicine)

  • Yang Liu

    (Decipher Biosciences)

  • Adrianna A. Mendes

    (Johns Hopkins University School of Medicine)

  • Daniela C. Salles

    (Johns Hopkins University School of Medicine)

  • Farzana A. Faisal

    (Johns Hopkins University School of Medicine)

  • Sanjana Murali

    (Johns Hopkins University School of Medicine)

  • Matthew McFarlane

    (University of Michigan)

  • Eddie L. Imada

    (Johns Hopkins University School of Medicine)

  • Xin Zhao

    (Decipher Biosciences)

  • Ziwen Li

    (Decipher Biosciences)

  • Elai Davicioni

    (Decipher Biosciences)

  • Luigi Marchionni

    (Johns Hopkins University School of Medicine)

  • Arul M. Chinnaiyan

    (University of Michigan)

  • Stephen J. Freedland

    (Cedars-Sinai Medical Center
    Durham Veterans Affairs Health Care System)

  • Daniel E. Spratt

    (University of Michigan)

  • Jennifer D. Wu

    (Northwestern University Feinberg School of Medicine
    Northwestern University Feinberg School of Medicine)

  • Tamara L. Lotan

    (Johns Hopkins University School of Medicine)

  • Edward M. Schaeffer

    (Northwestern University Feinberg School of Medicine)

Abstract

Black men die more often of prostate cancer yet, interestingly, may derive greater survival benefits from immune-based treatment with sipuleucel-T. Since no signatures of immune-responsiveness exist for prostate cancer, we explored race-based immune-profiles to identify vulnerabilities. Here we show in multiple independent cohorts comprised of over 1,300 patient samples annotated with either self-identified race or genetic ancestry, prostate tumors from Black men or men of African ancestry have increases in plasma cell infiltrate and augmented markers of NK cell activity and IgG expression. These findings are associated with improved recurrence-free survival following surgery and nominate plasma cells as drivers of prostate cancer immune-responsiveness.

Suggested Citation

  • Adam B. Weiner & Thiago Vidotto & Yang Liu & Adrianna A. Mendes & Daniela C. Salles & Farzana A. Faisal & Sanjana Murali & Matthew McFarlane & Eddie L. Imada & Xin Zhao & Ziwen Li & Elai Davicioni & L, 2021. "Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21245-w
    DOI: 10.1038/s41467-021-21245-w
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