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The metabolic impact of small intestinal nutrient sensing

Author

Listed:
  • Frank A. Duca

    (University of Arizona
    University of Arizona)

  • T. M. Zaved Waise

    (Toronto General Hospital Research Institute, UHN)

  • Willem T. Peppler

    (Toronto General Hospital Research Institute, UHN)

  • Tony K. T. Lam

    (Toronto General Hospital Research Institute, UHN
    University of Toronto
    University of Toronto
    University of Toronto)

Abstract

The gastrointestinal tract maintains energy and glucose homeostasis, in part through nutrient-sensing and subsequent signaling to the brain and other tissues. In this review, we highlight the role of small intestinal nutrient-sensing in metabolic homeostasis, and link high-fat feeding, obesity, and diabetes with perturbations in these gut-brain signaling pathways. We identify how lipids, carbohydrates, and proteins, initiate gut peptide release from the enteroendocrine cells through small intestinal sensing pathways, and how these peptides regulate food intake, glucose tolerance, and hepatic glucose production. Lastly, we highlight how the gut microbiota impact small intestinal nutrient-sensing in normal physiology, and in disease, pharmacological and surgical settings. Emerging evidence indicates that the molecular mechanisms of small intestinal nutrient sensing in metabolic homeostasis have physiological and pathological impact as well as therapeutic potential in obesity and diabetes.

Suggested Citation

  • Frank A. Duca & T. M. Zaved Waise & Willem T. Peppler & Tony K. T. Lam, 2021. "The metabolic impact of small intestinal nutrient sensing," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21235-y
    DOI: 10.1038/s41467-021-21235-y
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    Cited by:

    1. Song-Yang Zhang & Tony K. T. Lam, 2022. "Metabolic regulation by the intestinal metformin-AMPK axis," Nature Communications, Nature, vol. 13(1), pages 1-3, December.
    2. Junjun Gao & Song Zhang & Pan Deng & Zhigang Wu & Bruno Lemaitre & Zongzhao Zhai & Zheng Guo, 2024. "Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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