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Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains

Author

Listed:
  • Fabien Aubry

    (Institut Pasteur, UMR2000, CNRS)

  • Sofie Jacobs

    (Laboratory of Virology and Chemotherapy)

  • Maïlis Darmuzey

    (University of Liège)

  • Sebastian Lequime

    (Laboratory of Clinical and Epidemiological Virology
    University of Groningen)

  • Leen Delang

    (Laboratory of Virology and Chemotherapy)

  • Albin Fontaine

    (Institut de Recherche Biomédicale des Armées (IRBA)
    Aix Marseille University
    IHU Méditerranée Infection)

  • Natapong Jupatanakul

    (Institut Pasteur, UMR2000, CNRS
    National Center for Genetic Engineering and Biotechnology (BIOTEC))

  • Elliott F. Miot

    (Institut Pasteur, UMR2000, CNRS)

  • Stéphanie Dabo

    (Institut Pasteur, UMR2000, CNRS)

  • Caroline Manet

    (Institut Pasteur)

  • Xavier Montagutelli

    (Institut Pasteur)

  • Artem Baidaliuk

    (Institut Pasteur, UMR2000, CNRS
    Institut Pasteur)

  • Fabiana Gámbaro

    (Institut Pasteur)

  • Etienne Simon-Lorière

    (Institut Pasteur)

  • Maxime Gilsoul

    (University of Liège)

  • Claudia M. Romero-Vivas

    (Fundación Universidad del Norte)

  • Van-Mai Cao-Lormeau

    (Institut Louis Malardé)

  • Richard G. Jarman

    (Walter Reed Army Institute of Research)

  • Cheikh T. Diagne

    (Institut Pasteur Dakar)

  • Oumar Faye

    (Institut Pasteur Dakar)

  • Ousmane Faye

    (Institut Pasteur Dakar)

  • Amadou A. Sall

    (Institut Pasteur Dakar)

  • Johan Neyts

    (Laboratory of Virology and Chemotherapy)

  • Laurent Nguyen

    (University of Liège)

  • Suzanne J. F. Kaptein

    (Laboratory of Virology and Chemotherapy)

  • Louis Lambrechts

    (Institut Pasteur, UMR2000, CNRS)

Abstract

The global emergence of Zika virus (ZIKV) revealed the unprecedented ability for a mosquito-borne virus to cause congenital birth defects. A puzzling aspect of ZIKV emergence is that all human outbreaks and birth defects to date have been exclusively associated with the Asian ZIKV lineage, despite a growing body of laboratory evidence pointing towards higher transmissibility and pathogenicity of the African ZIKV lineage. Whether this apparent paradox reflects the use of relatively old African ZIKV strains in most laboratory studies is unclear. Here, we experimentally compare seven low-passage ZIKV strains representing the recently circulating viral genetic diversity. We find that recent African ZIKV strains display higher transmissibility in mosquitoes and higher lethality in both adult and fetal mice than their Asian counterparts. We emphasize the high epidemic potential of African ZIKV strains and suggest that they could more easily go unnoticed by public health surveillance systems than Asian strains due to their propensity to cause fetal loss rather than birth defects.

Suggested Citation

  • Fabien Aubry & Sofie Jacobs & Maïlis Darmuzey & Sebastian Lequime & Leen Delang & Albin Fontaine & Natapong Jupatanakul & Elliott F. Miot & Stéphanie Dabo & Caroline Manet & Xavier Montagutelli & Arte, 2021. "Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21199-z
    DOI: 10.1038/s41467-021-21199-z
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    Cited by:

    1. Charlotte Lefèvre & Georgia M. Cook & Adam M. Dinan & Shiho Torii & Hazel Stewart & George Gibbons & Alex S. Nicholson & Liliana Echavarría-Consuegra & Luke W. Meredith & Valeria Lulla & Naomi McGover, 2024. "Zika viruses encode 5′ upstream open reading frames affecting infection of human brain cells," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Thomas Obadia & Gladys Gutierrez-Bugallo & Veasna Duong & Ana I. Nuñez & Rosilainy S. Fernandes & Basile Kamgang & Liza Hery & Yann Gomard & Sandra R. Abbo & Davy Jiolle & Uros Glavinic & Myrielle Dup, 2022. "Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    3. Guang-Yuan Song & Xing-Yao Huang & Meng-Jiao He & Hang-Yu Zhou & Rui-Ting Li & Ying Tian & Yan Wang & Meng-Li Cheng & Xiang Chen & Rong-Rong Zhang & Chao Zhou & Jia Zhou & Xian-Yang Fang & Xiao-Feng L, 2023. "A single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotype," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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