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Genetic predictors of participation in optional components of UK Biobank

Author

Listed:
  • Jessica Tyrrell

    (University of Exeter)

  • Jie Zheng

    (University of Bristol
    University of Bristol)

  • Robin Beaumont

    (University of Exeter)

  • Kathryn Hinton

    (University of Exeter)

  • Tom G. Richardson

    (University of Bristol
    University of Bristol)

  • Andrew R. Wood

    (University of Exeter)

  • George Davey Smith

    (University of Bristol
    University of Bristol)

  • Timothy M. Frayling

    (University of Exeter)

  • Kate Tilling

    (University of Bristol
    University of Bristol)

Abstract

Large studies such as UK Biobank are increasingly used for GWAS and Mendelian randomization (MR) studies. However, selection into and dropout from studies may bias genetic and phenotypic associations. We examine genetic factors affecting participation in four optional components in up to 451,306 UK Biobank participants. We used GWAS to identify genetic variants associated with participation, MR to estimate effects of phenotypes on participation, and genetic correlations to compare participation bias across different studies. 32 variants were associated with participation in one of the optional components (P

Suggested Citation

  • Jessica Tyrrell & Jie Zheng & Robin Beaumont & Kathryn Hinton & Tom G. Richardson & Andrew R. Wood & George Davey Smith & Timothy M. Frayling & Kate Tilling, 2021. "Genetic predictors of participation in optional components of UK Biobank," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21073-y
    DOI: 10.1038/s41467-021-21073-y
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    Cited by:

    1. Tabea Schoeler & Doug Speed & Eleonora Porcu & Nicola Pirastu & Jean-Baptiste Pingault & Zoltán Kutalik, 2023. "Participation bias in the UK Biobank distorts genetic associations and downstream analyses," Nature Human Behaviour, Nature, vol. 7(7), pages 1216-1227, July.
    2. Gianmarco Mignogna & Caitlin E. Carey & Robbee Wedow & Nikolas Baya & Mattia Cordioli & Nicola Pirastu & Rino Bellocco & Kathryn Fiuza Malerbi & Michel G. Nivard & Benjamin M. Neale & Raymond K. Walte, 2023. "Patterns of item nonresponse behaviour to survey questionnaires are systematic and associated with genetic loci," Nature Human Behaviour, Nature, vol. 7(8), pages 1371-1387, August.
    3. Caitlin E. Carey & Rebecca Shafee & Robbee Wedow & Amanda Elliott & Duncan S. Palmer & John Compitello & Masahiro Kanai & Liam Abbott & Patrick Schultz & Konrad J. Karczewski & Samuel C. Bryant & Caro, 2024. "Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation," Nature Human Behaviour, Nature, vol. 8(8), pages 1599-1615, August.

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