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The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis

Author

Listed:
  • Ivo S. Muskens

    (Keck School of Medicine of the University of Southern California
    University of Southern California)

  • Shaobo Li

    (Keck School of Medicine of the University of Southern California
    University of Southern California)

  • Thomas Jackson

    (NIHR Oxford Biomedical Centre)

  • Natalina Elliot

    (NIHR Oxford Biomedical Centre)

  • Helen M. Hansen

    (University of California San Francisco)

  • Swe Swe Myint

    (Keck School of Medicine of the University of Southern California
    University of Southern California)

  • Priyatama Pandey

    (Keck School of Medicine of the University of Southern California
    University of Southern California)

  • Jeremy M. Schraw

    (Baylor College of Medicine
    Texas Children’s Hospital)

  • Ritu Roy

    (University of California San Francisco)

  • Joaquin Anguiano

    (University of California San Francisco)

  • Katerina Goudevenou

    (NIHR Oxford Biomedical Centre)

  • Kimberly D. Siegmund

    (Keck School of Medicine of the University of Southern California)

  • Philip J. Lupo

    (Baylor College of Medicine
    Texas Children’s Hospital)

  • Marella F. T. R. de Bruijn

    (University of Oxford)

  • Kyle M. Walsh

    (Duke University
    Duke University)

  • Paresh Vyas

    (University of Oxford)

  • Xiaomei Ma

    (Yale School of Public Health)

  • Anindita Roy

    (NIHR Oxford Biomedical Centre)

  • Irene Roberts

    (NIHR Oxford Biomedical Centre)

  • Joseph L. Wiemels

    (Keck School of Medicine of the University of Southern California
    University of Southern California)

  • Adam J. de Smith

    (Keck School of Medicine of the University of Southern California
    University of Southern California)

Abstract

Down syndrome is associated with genome-wide perturbation of gene expression, which may be mediated by epigenetic changes. We perform an epigenome-wide association study on neonatal bloodspots comparing 196 newborns with Down syndrome and 439 newborns without Down syndrome, adjusting for cell-type heterogeneity, which identifies 652 epigenome-wide significant CpGs (P

Suggested Citation

  • Ivo S. Muskens & Shaobo Li & Thomas Jackson & Natalina Elliot & Helen M. Hansen & Swe Swe Myint & Priyatama Pandey & Jeremy M. Schraw & Ritu Roy & Joaquin Anguiano & Katerina Goudevenou & Kimberly D. , 2021. "The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21064-z
    DOI: 10.1038/s41467-021-21064-z
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