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GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility

Author

Listed:
  • Daniel Eriksson

    (Karolinska Institutet
    Uppsala University Hospital
    Uppsala University)

  • Ellen Christine Røyrvik

    (University of Bergen
    University of Bergen)

  • Maribel Aranda-Guillén

    (Karolinska Institutet)

  • Amund Holte Berger

    (University of Bergen
    University of Bergen
    Haukeland University Hospital)

  • Nils Landegren

    (Karolinska Institutet
    Uppsala University)

  • Haydee Artaza

    (University of Bergen
    University of Bergen)

  • Åsa Hallgren

    (Karolinska Institutet)

  • Marianne Aardal Grytaas

    (University of Bergen
    Haukeland University Hospital)

  • Sara Ström

    (Karolinska University Hospital
    Karolinska Institutet)

  • Eirik Bratland

    (University of Bergen
    University of Bergen
    Haukeland University Hospital)

  • Ileana Ruxandra Botusan

    (Karolinska University Hospital
    Karolinska Institutet)

  • Bergithe Eikeland Oftedal

    (University of Bergen
    University of Bergen)

  • Lars Breivik

    (University of Bergen
    Haukeland University Hospital)

  • Marc Vaudel

    (University of Bergen)

  • Øyvind Helgeland

    (University of Bergen
    Institute of Public Health)

  • Alberto Falorni

    (University of Perugia)

  • Anders Palmstrøm Jørgensen

    (Oslo University Hospital)

  • Anna-Lena Hulting

    (Karolinska Institutet)

  • Johan Svartberg

    (UiT The Arctic University of Norway
    University Hospital of North Norway)

  • Olov Ekwall

    (University of Gothenburg
    University of Gothenburg)

  • Kristian Johan Fougner

    (St. Olavs Hospital)

  • Jeanette Wahlberg

    (Linköping University
    Linköping University)

  • Bjørn Gunnar Nedrebø

    (University of Bergen
    Haugesund Hospital)

  • Per Dahlqvist

    (Umeå University)

  • Per Morten Knappskog

    (University of Bergen
    University of Bergen
    Haukeland University Hospital)

  • Anette Susanne Bøe Wolff

    (University of Bergen
    University of Bergen)

  • Sophie Bensing

    (Karolinska University Hospital
    Karolinska Institutet)

  • Stefan Johansson

    (University of Bergen
    Haukeland University Hospital)

  • Olle Kämpe

    (Karolinska Institutet
    University of Bergen
    University of Bergen
    Karolinska University Hospital)

  • Eystein Sverre Husebye

    (Karolinska Institutet
    University of Bergen
    University of Bergen
    Haukeland University Hospital)

Abstract

Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on AAD, which identifies nine independent risk loci (P

Suggested Citation

  • Daniel Eriksson & Ellen Christine Røyrvik & Maribel Aranda-Guillén & Amund Holte Berger & Nils Landegren & Haydee Artaza & Åsa Hallgren & Marianne Aardal Grytaas & Sara Ström & Eirik Bratland & Ileana, 2021. "GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21015-8
    DOI: 10.1038/s41467-021-21015-8
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