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Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2

Author

Listed:
  • Antoni G. Wrobel

    (Francis Crick Institute, NW1 1AT)

  • Donald J. Benton

    (Francis Crick Institute, NW1 1AT)

  • Pengqi Xu

    (Francis Crick Institute, NW1 1AT
    Sun Yat-sen University, Shenzhen)

  • Lesley J. Calder

    (Francis Crick Institute, NW1 1AT)

  • Annabel Borg

    (Francis Crick Institute, NW1 1AT)

  • Chloë Roustan

    (Francis Crick Institute, NW1 1AT)

  • Stephen R. Martin

    (Francis Crick Institute, NW1 1AT)

  • Peter B. Rosenthal

    (Francis Crick Institute, NW1 1AT)

  • John J. Skehel

    (Francis Crick Institute, NW1 1AT)

  • Steven J. Gamblin

    (Francis Crick Institute, NW1 1AT)

Abstract

Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV spike protein and show it adopts a fully-closed conformation and that, aside from the Receptor-Binding Domain, it resembles the spike of a bat coronavirus RaTG13 more than that of SARS-CoV-2.

Suggested Citation

  • Antoni G. Wrobel & Donald J. Benton & Pengqi Xu & Lesley J. Calder & Annabel Borg & Chloë Roustan & Stephen R. Martin & Peter B. Rosenthal & John J. Skehel & Steven J. Gamblin, 2021. "Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2," Nature Communications, Nature, vol. 12(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21006-9
    DOI: 10.1038/s41467-021-21006-9
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    Cited by:

    1. Antoni G. Wrobel & Donald J. Benton & Chloë Roustan & Annabel Borg & Saira Hussain & Stephen R. Martin & Peter B. Rosenthal & John J. Skehel & Steven J. Gamblin, 2022. "Evolution of the SARS-CoV-2 spike protein in the human host," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    2. Lena Jaki & Sebastian Weigang & Lisa Kern & Stefanie Kramme & Antoni G. Wrobel & Andrea B. Grawitz & Philipp Nawrath & Stephen R. Martin & Theo Dähne & Julius Beer & Miriam Disch & Philipp Kolb & Lisa, 2023. "Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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