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Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses

Author

Listed:
  • Shuo Li

    (Johns Hopkins University, School of Medicine
    Johns Hopkins Bloomberg School of Public Health)

  • Sumana Raychaudhuri

    (Johns Hopkins University, School of Medicine)

  • Stephen Alexander Lee

    (The Marine Biological Laboratory
    Columbia University)

  • Marisa M. Brockmann

    (Charité Universitätsmedizin)

  • Jing Wang

    (ThermoFisher Scientific)

  • Grant Kusick

    (Johns Hopkins University, School of Medicine
    Johns Hopkins University, School of Medicine)

  • Christine Prater

    (The Marine Biological Laboratory
    Texas Tech University Health Sciences Center)

  • Sarah Syed

    (Johns Hopkins University, School of Medicine)

  • Hanieh Falahati

    (The Marine Biological Laboratory
    Yale University School of Medicine)

  • Raul Ramos

    (The Marine Biological Laboratory
    Brandeis University)

  • Tomas M. Bartol

    (Salk Institute for Biological Studies)

  • Eric Hosy

    (Centre National de la Recherche Scientifique
    University of Bordeaux)

  • Shigeki Watanabe

    (Johns Hopkins University, School of Medicine
    Johns Hopkins University, School of Medicine)

Abstract

Neurotransmitter is released synchronously and asynchronously following an action potential. Our recent study indicates that the release sites of these two phases are segregated within an active zone, with asynchronous release sites enriched near the center in mouse hippocampal synapses. Here we demonstrate that synchronous and asynchronous release sites are aligned with AMPA receptor and NMDA receptor clusters, respectively. Computational simulations indicate that this spatial and temporal arrangement of release can lead to maximal membrane depolarization through AMPA receptors, alleviating the pore-blocking magnesium leading to greater activation of NMDA receptors. Together, these results suggest that release sites are likely organized to activate NMDA receptors efficiently.

Suggested Citation

  • Shuo Li & Sumana Raychaudhuri & Stephen Alexander Lee & Marisa M. Brockmann & Jing Wang & Grant Kusick & Christine Prater & Sarah Syed & Hanieh Falahati & Raul Ramos & Tomas M. Bartol & Eric Hosy & Sh, 2021. "Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21004-x
    DOI: 10.1038/s41467-021-21004-x
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    Cited by:

    1. Philipe R. F. Mendonça & Erica Tagliatti & Helen Langley & Dimitrios Kotzadimitriou & Criseida G. Zamora-Chimal & Yulia Timofeeva & Kirill E. Volynski, 2022. "Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Kyung Ah Han & Taek-Han Yoon & Jinhu Kim & Jusung Lee & Ju Yeon Lee & Gyubin Jang & Ji Won Um & Jong Kyoung Kim & Jaewon Ko, 2024. "Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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