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Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors

Author

Listed:
  • Cristina Valero

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Mark Lee

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Douglas Hoen

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Kate Weiss

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Daniel W. Kelly

    (Memorial Sloan Kettering Cancer Center)

  • Prasad S. Adusumilli

    (Memorial Sloan Kettering Cancer Center)

  • Paul K. Paik

    (Memorial Sloan Kettering Cancer Center)

  • George Plitas

    (Memorial Sloan Kettering Cancer Center)

  • Marc Ladanyi

    (Memorial Sloan Kettering Cancer Center)

  • Michael A. Postow

    (Memorial Sloan Kettering Cancer Center)

  • Charlotte E. Ariyan

    (Memorial Sloan Kettering Cancer Center)

  • Alexander N. Shoushtari

    (Memorial Sloan Kettering Cancer Center)

  • Vinod P. Balachandran

    (Memorial Sloan Kettering Cancer Center)

  • A. Ari Hakimi

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Aimee M. Crago

    (Memorial Sloan Kettering Cancer Center)

  • Kara C. Long Roche

    (Memorial Sloan Kettering Cancer Center)

  • J. Joshua Smith

    (Memorial Sloan Kettering Cancer Center)

  • Ian Ganly

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Richard J. Wong

    (Memorial Sloan Kettering Cancer Center)

  • Snehal G. Patel

    (Memorial Sloan Kettering Cancer Center)

  • Jatin P. Shah

    (Memorial Sloan Kettering Cancer Center)

  • Nancy Y. Lee

    (Memorial Sloan Kettering Cancer Center)

  • Nadeem Riaz

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Jingming Wang

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Ahmet Zehir

    (Memorial Sloan Kettering Cancer Center)

  • Michael F. Berger

    (Memorial Sloan Kettering Cancer Center)

  • Timothy A. Chan

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Venkatraman E. Seshan

    (Memorial Sloan Kettering Cancer Center)

  • Luc G. T. Morris

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

Abstract

Treatment with immune checkpoint inhibitors (ICI) has demonstrated clinical benefit for a wide range of cancer types. Because only a subset of patients experience clinical benefit, there is a strong need for biomarkers that are easily accessible across diverse practice settings. Here, in a retrospective cohort study of 1714 patients with 16 different cancer types treated with ICI, we show that higher neutrophil-to-lymphocyte ratio (NLR) is significantly associated with poorer overall and progression-free survival, and lower rates of response and clinical benefit, after ICI therapy across multiple cancer types. Combining NLR with tumor mutational burden (TMB), the probability of benefit from ICI is significantly higher (OR = 3.22; 95% CI, 2.26-4.58; P

Suggested Citation

  • Cristina Valero & Mark Lee & Douglas Hoen & Kate Weiss & Daniel W. Kelly & Prasad S. Adusumilli & Paul K. Paik & George Plitas & Marc Ladanyi & Michael A. Postow & Charlotte E. Ariyan & Alexander N. S, 2021. "Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-20935-9
    DOI: 10.1038/s41467-021-20935-9
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    Cited by:

    1. Antti Kiviaho & Sini K. Eerola & Heini M. L. Kallio & Maria K. Andersen & Miina Hoikka & Aliisa M. Tiihonen & Iida Salonen & Xander Spotbeen & Alexander Giesen & Charles T. A. Parker & Sinja Taavitsai, 2024. "Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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