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Association of PET-based estradiol-challenge test for breast cancer progesterone receptors with response to endocrine therapy

Author

Listed:
  • Farrokh Dehdashti

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Ningying Wu

    (Washington University School of Medicine
    Department of Surgery Washington University School of Medicine)

  • Cynthia X. Ma

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Michael J. Naughton

    (Saint Francis Healthcare, Cape Medical Oncology)

  • John A. Katzenellenbogen

    (University of Illinois)

  • Barry A. Siegel

    (Washington University School of Medicine
    Washington University School of Medicine)

Abstract

Estrogen receptor (ER) testing of breast cancer imperfectly predicts response to endocrine therapy (ET). We hypothesize that a brief estradiol challenge will increase tumor progesterone receptor (PgR) levels only in tumors with functional ER. In this prospective, phase 2, single-center, single-arm trial (NCT02455453), we report the association of response to ET with change in tumor uptake of the progestin analog, 21-[18F]fluorofuranylnorprogesterone (FFNP), before and after a one-day estradiol challenge. In 43 postmenopausal women with advanced ER+ breast cancer, we show a post-challenge increase in tumor FFNP uptake only in 28 subjects with clinical benefit from ET (responders), but not in 15 without clinical benefit (nonresponders) (p

Suggested Citation

  • Farrokh Dehdashti & Ningying Wu & Cynthia X. Ma & Michael J. Naughton & John A. Katzenellenbogen & Barry A. Siegel, 2021. "Association of PET-based estradiol-challenge test for breast cancer progesterone receptors with response to endocrine therapy," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20814-9
    DOI: 10.1038/s41467-020-20814-9
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