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Stable inheritance of Sinorhizobium meliloti cell growth polarity requires an FtsN-like protein and an amidase

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  • Elizaveta Krol

    (Philipps-Universität Marburg
    Philipps-Universität Marburg)

  • Lisa Stuckenschneider

    (Philipps-Universität Marburg
    Philipps-Universität Marburg)

  • Joana M. Kästle Silva

    (Philipps-Universität Marburg
    Max Planck Institute for Terrestrial Microbiology)

  • Peter L. Graumann

    (Philipps-Universität Marburg
    Philipps-Universität Marburg)

  • Anke Becker

    (Philipps-Universität Marburg
    Philipps-Universität Marburg)

Abstract

In Rhizobiales bacteria, such as Sinorhizobium meliloti, cell elongation takes place only at new cell poles, generated by cell division. Here, we show that the role of the FtsN-like protein RgsS in S. meliloti extends beyond cell division. RgsS contains a conserved SPOR domain known to bind amidase-processed peptidoglycan. This part of RgsS and peptidoglycan amidase AmiC are crucial for reliable selection of the new cell pole as cell elongation zone. Absence of these components increases mobility of RgsS molecules, as well as abnormal RgsS accumulation and positioning of the growth zone at the old cell pole in about one third of the cells. These cells with inverted growth polarity are able to complete the cell cycle but show partially impaired chromosome segregation. We propose that amidase-processed peptidoglycan provides a landmark for RgsS to generate cell polarity in unipolarly growing Rhizobiales.

Suggested Citation

  • Elizaveta Krol & Lisa Stuckenschneider & Joana M. Kästle Silva & Peter L. Graumann & Anke Becker, 2021. "Stable inheritance of Sinorhizobium meliloti cell growth polarity requires an FtsN-like protein and an amidase," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20739-3
    DOI: 10.1038/s41467-020-20739-3
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    Cited by:

    1. Caroline Servais & Victoria Vassen & Audrey Verhaeghe & Nina Küster & Elodie Carlier & Léa Phégnon & Aurélie Mayard & Nicolas Auberger & Stéphane Vincent & Xavier De Bolle, 2023. "Lipopolysaccharide biosynthesis and traffic in the envelope of the pathogen Brucella abortus," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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