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Sequencing of the Arabidopsis NOR2 reveals its distinct organization and tissue-specific rRNA ribosomal variants

Author

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  • Jason Sims

    (University of Vienna, Vienna BioCenter)

  • Giovanni Sestini

    (University of Vienna, Vienna BioCenter
    Vienna Biocenter (VBC))

  • Christiane Elgert

    (University of Vienna and Medical University of Vienna, Vienna BioCenter)

  • Arndt von Haeseler

    (University of Vienna and Medical University of Vienna, Vienna BioCenter)

  • Peter Schlögelhofer

    (University of Vienna, Vienna BioCenter)

Abstract

Despite vast differences between organisms, some characteristics of their genomes are conserved, such as the nucleolus organizing region (NOR). The NOR is constituted of multiple, highly repetitive rDNA genes, encoding the catalytic ribosomal core RNAs which are transcribed from 45S rDNA units. Their precise sequence information and organization remain uncharacterized. Here, using a combination of long- and short-read sequencing technologies we assemble contigs of the Arabidopsis NOR2 rDNA domain. We identify several expressed rRNA gene variants which are integrated into translating ribosomes in a tissue-specific manner. These findings support the concept of tissue specific ribosome subpopulations that differ in their rRNA composition and provide insights into the higher order organization of NOR2.

Suggested Citation

  • Jason Sims & Giovanni Sestini & Christiane Elgert & Arndt von Haeseler & Peter Schlögelhofer, 2021. "Sequencing of the Arabidopsis NOR2 reveals its distinct organization and tissue-specific rRNA ribosomal variants," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20728-6
    DOI: 10.1038/s41467-020-20728-6
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    Cited by:

    1. Daniel Sultanov & Andreas Hochwagen, 2022. "Varying strength of selection contributes to the intragenomic diversity of rRNA genes," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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