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Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation

Author

Listed:
  • Shihao Zhang

    (Hubei University)

  • Xilan Yu

    (Hubei University)

  • Yuan Zhang

    (Hubei University)

  • Xiangyan Xue

    (Hubei University)

  • Qi Yu

    (Hubei University)

  • Zitong Zha

    (Nanchang University)

  • Madelaine Gogol

    (Stowers Institute for Medical Research)

  • Jerry L. Workman

    (Stowers Institute for Medical Research)

  • Shanshan Li

    (Hubei University)

Abstract

Telomeres are organized into a heterochromatin structure and maintenance of silent heterochromatin is required for chromosome stability. How telomere heterochromatin is dynamically regulated in response to stimuli remains unknown. Pyruvate kinase Pyk1 forms a complex named SESAME (Serine-responsive SAM-containing Metabolic Enzyme complex) to regulate gene expression by phosphorylating histone H3T11 (H3pT11). Here, we identify a function of SESAME in regulating telomere heterochromatin structure. SESAME phosphorylates H3T11 at telomeres, which maintains SIR (silent information regulator) complex occupancy at telomeres and protects Sir2 from degradation by autophagy. Moreover, SESAME-catalyzed H3pT11 directly represses autophagy-related gene expression to further prevent autophagy-mediated Sir2 degradation. By promoting H3pT11, serine increases Sir2 protein levels and enhances telomere silencing. Loss of H3pT11 leads to reduced Sir2 and compromised telomere silencing during chronological aging. Together, our study provides insights into dynamic regulation of silent heterochromatin by histone modifications and autophagy in response to cell metabolism and aging.

Suggested Citation

  • Shihao Zhang & Xilan Yu & Yuan Zhang & Xiangyan Xue & Qi Yu & Zitong Zha & Madelaine Gogol & Jerry L. Workman & Shanshan Li, 2021. "Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20711-1
    DOI: 10.1038/s41467-020-20711-1
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    Cited by:

    1. Fei He & Qi Yu & Min Wang & Rongsha Wang & Xuanyunjing Gong & Feng Ge & Xilan Yu & Shanshan Li, 2022. "SESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencing," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Qi Yu & Xuanyunjing Gong & Yue Tong & Min Wang & Kai Duan & Xinyu Zhang & Feng Ge & Xilan Yu & Shanshan Li, 2022. "Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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