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Genetic determinants of daytime napping and effects on cardiometabolic health

Author

Listed:
  • Hassan S. Dashti

    (Massachusetts General Hospital and Harvard Medical School
    Broad Institute
    Massachusetts General Hospital and Harvard Medical School)

  • Iyas Daghlas

    (Massachusetts General Hospital and Harvard Medical School
    Broad Institute)

  • Jacqueline M. Lane

    (Massachusetts General Hospital and Harvard Medical School
    Broad Institute
    Massachusetts General Hospital and Harvard Medical School)

  • Yunru Huang

    (23andMe, Inc.)

  • Miriam S. Udler

    (Massachusetts General Hospital and Harvard Medical School
    Broad Institute
    Massachusetts General Hospital
    Harvard Medical School)

  • Heming Wang

    (Broad Institute
    Brigham and Women’s Hospital and Harvard Medical School)

  • Hanna M. Ollila

    (Massachusetts General Hospital and Harvard Medical School
    Broad Institute
    University of Helsinki
    Stanford University)

  • Samuel E. Jones

    (University of Helsinki
    University of Exeter Medical School)

  • Jaegil Kim

    (GlaxoSmithKline)

  • Andrew R. Wood

    (University of Exeter Medical School)

  • Michael N. Weedon

    (University of Exeter Medical School)

  • Stella Aslibekyan

    (23andMe, Inc.)

  • Marta Garaulet

    (Brigham and Women’s Hospital and Harvard Medical School
    University of Murcia
    IMIB-Arrixaca)

  • Richa Saxena

    (Massachusetts General Hospital and Harvard Medical School
    Broad Institute
    Massachusetts General Hospital and Harvard Medical School)

Abstract

Daytime napping is a common, heritable behavior, but its genetic basis and causal relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide association study of self-reported daytime napping in the UK Biobank (n = 452,633) and identify 123 loci of which 61 replicate in the 23andMe research cohort (n = 541,333). Findings include missense variants in established drug targets for sleep disorders (HCRTR1, HCRTR2), genes with roles in arousal (TRPC6, PNOC), and genes suggesting an obesity-hypersomnolence pathway (PNOC, PATJ). Association signals are concordant with accelerometer-measured daytime inactivity duration and 33 loci colocalize with loci for other sleep phenotypes. Cluster analysis identifies three distinct clusters of nap-promoting mechanisms with heterogeneous associations with cardiometabolic outcomes. Mendelian randomization shows potential causal links between more frequent daytime napping and higher blood pressure and waist circumference.

Suggested Citation

  • Hassan S. Dashti & Iyas Daghlas & Jacqueline M. Lane & Yunru Huang & Miriam S. Udler & Heming Wang & Hanna M. Ollila & Samuel E. Jones & Jaegil Kim & Andrew R. Wood & Michael N. Weedon & Stella Aslibe, 2021. "Genetic determinants of daytime napping and effects on cardiometabolic health," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20585-3
    DOI: 10.1038/s41467-020-20585-3
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