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Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

Author

Listed:
  • Jeroen J. A. Kampen

    (Erasmus MC)

  • David A. M. C. Vijver

    (Erasmus MC)

  • Pieter L. A. Fraaij

    (Erasmus MC
    Subdivision Infectious Diseases and Immunology, Erasmus MC - Sophia)

  • Bart L. Haagmans

    (Erasmus MC)

  • Mart M. Lamers

    (Erasmus MC)

  • Nisreen Okba

    (Erasmus MC)

  • Johannes P. C. Akker

    (Erasmus MC)

  • Henrik Endeman

    (Erasmus MC)

  • Diederik A. M. P. J. Gommers

    (Erasmus MC)

  • Jan J. Cornelissen

    (Erasmus MC)

  • Rogier A. S. Hoek

    (Erasmus MC
    Erasmus MC Transplant Institute)

  • Menno M. Eerden

    (Erasmus MC)

  • Dennis A. Hesselink

    (Erasmus MC Transplant Institute
    Erasmus MC)

  • Herold J. Metselaar

    (Erasmus MC Transplant Institute
    Erasmus MC)

  • Annelies Verbon

    (Erasmus MC)

  • Jurriaan E. M. Steenwinkel

    (Erasmus MC)

  • Georgina I. Aron

    (Erasmus MC)

  • Eric C. M. Gorp

    (Erasmus MC)

  • Sander Boheemen

    (Erasmus MC)

  • Jolanda C. Voermans

    (Erasmus MC)

  • Charles A. B. Boucher

    (Erasmus MC)

  • Richard Molenkamp

    (Erasmus MC)

  • Marion P. G. Koopmans

    (Erasmus MC)

  • Corine Geurtsvankessel

    (Erasmus MC)

  • Annemiek A. Eijk

    (Erasmus MC)

Abstract

Key questions in COVID-19 are the duration and determinants of infectious virus shedding. Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 patients (17.8%) hospitalized with COVID-19. The median duration of shedding infectious virus is 8 days post onset of symptoms (IQR 5–11) and drops below 5% after 15.2 days post onset of symptoms (95% confidence interval (CI) 13.4–17.2). Multivariate analyses identify viral loads above 7 log10 RNA copies/mL (odds ratio [OR] of 14.7 (CI 3.57-58.1; p

Suggested Citation

  • Jeroen J. A. Kampen & David A. M. C. Vijver & Pieter L. A. Fraaij & Bart L. Haagmans & Mart M. Lamers & Nisreen Okba & Johannes P. C. Akker & Henrik Endeman & Diederik A. M. P. J. Gommers & Jan J. Cor, 2021. "Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)," Nature Communications, Nature, vol. 12(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20568-4
    DOI: 10.1038/s41467-020-20568-4
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    Cited by:

    1. Shakhany, Mohammad Qaleh & Salimifard, Khodakaram, 2021. "Predicting the dynamical behavior of COVID-19 epidemic and the effect of control strategies," Chaos, Solitons & Fractals, Elsevier, vol. 146(C).

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