IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-020-20523-3.html
   My bibliography  Save this article

PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

Author

Listed:
  • Pojeong Park

    (University of Bristol
    Seoul National University
    Mount Sinai Hospital
    University of Toronto)

  • John Georgiou

    (Mount Sinai Hospital)

  • Thomas M. Sanderson

    (University of Bristol
    Seoul National University
    Mount Sinai Hospital)

  • Kwang-Hee Ko

    (Seoul National University)

  • Heather Kang

    (University of Bristol
    Seoul National University
    Mount Sinai Hospital
    University of Toronto)

  • Ji-il Kim

    (Seoul National University)

  • Clarrisa A. Bradley

    (Seoul National University
    The Hospital for Sick Children)

  • Zuner A. Bortolotto

    (University of Bristol)

  • Min Zhuo

    (Seoul National University
    University of Toronto)

  • Bong-Kiun Kaang

    (Seoul National University)

  • Graham L. Collingridge

    (University of Bristol
    Seoul National University
    Mount Sinai Hospital
    University of Toronto)

Abstract

Long-term potentiation (LTP) at hippocampal CA1 synapses can be expressed by an increase either in the number (N) of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors or in their single channel conductance (γ). Here, we have established how these distinct synaptic processes contribute to the expression of LTP in hippocampal slices obtained from young adult rodents. LTP induced by compressed theta burst stimulation (TBS), with a 10 s inter-episode interval, involves purely an increase in N (LTPN). In contrast, either a spaced TBS, with a 10 min inter-episode interval, or a single TBS, delivered when PKA is activated, results in LTP that is associated with a transient increase in γ (LTPγ), caused by the insertion of calcium-permeable (CP)-AMPA receptors. Activation of CaMKII is necessary and sufficient for LTPN whilst PKA is additionally required for LTPγ. Thus, two mechanistically distinct forms of LTP co-exist at these synapses.

Suggested Citation

  • Pojeong Park & John Georgiou & Thomas M. Sanderson & Kwang-Hee Ko & Heather Kang & Ji-il Kim & Clarrisa A. Bradley & Zuner A. Bortolotto & Min Zhuo & Bong-Kiun Kaang & Graham L. Collingridge, 2021. "PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20523-3
    DOI: 10.1038/s41467-020-20523-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-20523-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-20523-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20523-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.