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Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram

Author

Listed:
  • Dexin Chen

    (Southern Medical University
    Jimei University)

  • Zhangyuanzhu Liu

    (The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine)

  • Wenju Liu

    (Southern Medical University
    Fujian Medical University Cancer Hospital and Fujian Cancer Hospital
    Fujian Provincial Cancer Hospital)

  • Meiting Fu

    (Nanfang Hospital, Southern Medical University)

  • Wei Jiang

    (Southern Medical University)

  • Shuoyu Xu

    (Southern Medical University
    Sun Yat-sen University Cancer Center)

  • Guangxing Wang

    (Jimei University
    Fujian Normal University)

  • Feng Chen

    (The Second Affiliated Hospital of Fujian Medical University)

  • Jianping Lu

    (Fujian Medical University Cancer Hospital and Fujian Cancer Hospital
    Fujian Provincial Cancer Hospital)

  • Hao Chen

    (Southern Medical University)

  • Xiaoyu Dong

    (Southern Medical University)

  • Guoxin Li

    (Southern Medical University)

  • Gang Chen

    (Fujian Medical University Cancer Hospital and Fujian Cancer Hospital
    Fujian Provincial Cancer Hospital)

  • Shuangmu Zhuo

    (Jimei University)

  • Jun Yan

    (Southern Medical University
    Fujian Provincial Cancer Hospital)

Abstract

Accurate prediction of peritoneal metastasis for gastric cancer (GC) with serosal invasion is crucial in clinic. The presence of collagen in the tumour microenvironment affects the metastasis of cancer cells. Herein, we propose a collagen signature, which is composed of multiple collagen features in the tumour microenvironment of the serosa derived from multiphoton imaging, to describe the extent of collagen alterations. We find that a high collagen signature is significantly associated with a high risk of peritoneal metastasis (P

Suggested Citation

  • Dexin Chen & Zhangyuanzhu Liu & Wenju Liu & Meiting Fu & Wei Jiang & Shuoyu Xu & Guangxing Wang & Feng Chen & Jianping Lu & Hao Chen & Xiaoyu Dong & Guoxin Li & Gang Chen & Shuangmu Zhuo & Jun Yan, 2021. "Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20429-0
    DOI: 10.1038/s41467-020-20429-0
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