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Resilin-mimetics as a smart biomaterial platform for biomedical applications

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  • Rajkamal Balu

    (RMIT University)

  • Naba K. Dutta

    (RMIT University)

  • Ankit K. Dutta

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Namita Roy Choudhury

    (RMIT University)

Abstract

Intrinsically disordered proteins have dramatically changed the structure–function paradigm of proteins in the 21st century. Resilin is a native elastic insect protein, which features intrinsically disordered structure, unusual multi-stimuli responsiveness and outstanding resilience. Advances in computational techniques, polypeptide synthesis methods and modular protein engineering routines have led to the development of novel resilin-like polypeptides (RLPs) including modular RLPs, expanding their applications in tissue engineering, drug delivery, bioimaging, biosensors, catalysis and bioelectronics. However, how the responsive behaviour of RLPs is encoded in the amino acid sequence level remains elusive. This review summarises the milestones of RLPs, and discusses the development of modular RLP-based biomaterials, their current applications, challenges and future perspectives. A perspective of future research is that sequence and responsiveness profiling of RLPs can provide a new platform for the design and development of new modular RLP-based biomaterials with programmable structure, properties and functions.

Suggested Citation

  • Rajkamal Balu & Naba K. Dutta & Ankit K. Dutta & Namita Roy Choudhury, 2021. "Resilin-mimetics as a smart biomaterial platform for biomedical applications," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20375-x
    DOI: 10.1038/s41467-020-20375-x
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    Cited by:

    1. Sheng-Chen Huang & Ya-Jiao Zhu & Xiao-Ying Huang & Xiao-Xia Xia & Zhi-Gang Qian, 2024. "Programmable adhesion and morphing of protein hydrogels for underwater robots," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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