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Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse

Author

Listed:
  • Yaqian Li

    (Chinese Academy of Medical Science and Peking Union Medical College)

  • Qing-Yang Zhang

    (Beijing Institute of Genomics, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Bao-Fa Sun

    (Beijing Institute of Genomics, Chinese Academy of Sciences
    China National Center for Bioinformation
    University of Chinese Academy of Sciences
    Institute of Stem Cell and Regeneration, Chinese Academy of Sciences)

  • Yidi Ma

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Ye Zhang

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Min Wang

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Congcong Ma

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Honghui Shi

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Zhijing Sun

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Juan Chen

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Yun-Gui Yang

    (Beijing Institute of Genomics, Chinese Academy of Sciences
    China National Center for Bioinformation
    University of Chinese Academy of Sciences
    Institute of Stem Cell and Regeneration, Chinese Academy of Sciences)

  • Lan Zhu

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

Abstract

Anterior vaginal prolapse (AVP) is the most common form of pelvic organ prolapse (POP) and has deleterious effects on women’s health. Despite recent advances in AVP diagnosis and treatment, a cell atlas of the vaginal wall in AVP has not been constructed. Here, we employ single-cell RNA-seq to construct a transcriptomic atlas of 81,026 individual cells in the vaginal wall from AVP and control samples and identify 11 cell types. We reveal aberrant gene expression in diverse cell types in AVP. Extracellular matrix (ECM) dysregulation and immune reactions involvement are identified in both non-immune and immune cell types. In addition, we find that several transcription factors associated with ECM and immune regulation are activated in AVP. Furthermore, we reveal dysregulated cell–cell communication patterns in AVP. Taken together, this work provides a valuable resource for deciphering the cellular heterogeneity and the molecular mechanisms underlying severe AVP.

Suggested Citation

  • Yaqian Li & Qing-Yang Zhang & Bao-Fa Sun & Yidi Ma & Ye Zhang & Min Wang & Congcong Ma & Honghui Shi & Zhijing Sun & Juan Chen & Yun-Gui Yang & Lan Zhu, 2021. "Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20358-y
    DOI: 10.1038/s41467-020-20358-y
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