IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-020-20307-9.html
   My bibliography  Save this article

TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens

Author

Listed:
  • Rikio Yabe

    (Tokyo University of Science
    Chiba University)

  • Soo-Hyun Chung

    (Tokyo University of Science)

  • Masanori A. Murayama

    (Tokyo University of Science)

  • Sachiko Kubo

    (Tokyo University of Science)

  • Kenji Shimizu

    (Tokyo University of Science)

  • Yukiko Akahori

    (Chiba University)

  • Takumi Maruhashi

    (Tokyo University of Science)

  • Akimasa Seno

    (Tokyo University of Science)

  • Tomonori Kaifu

    (Tokyo University of Science)

  • Shinobu Saijo

    (Chiba University)

  • Yoichiro Iwakura

    (Tokyo University of Science
    Chiba University)

Abstract

TARM1 is a member of the leukocyte immunoglobulin-like receptor family and stimulates macrophages and neutrophils in vitro by associating with FcRγ. However, the function of this molecule in the regulation of the immune system is unclear. Here, we show that Tarm1 expression is elevated in the joints of rheumatoid arthritis mouse models, and the development of collagen-induced arthritis (CIA) is suppressed in Tarm1–/– mice. T cell priming against type 2 collagen is suppressed in Tarm1–/– mice and antigen-presenting ability of GM-CSF-induced dendritic cells (GM-DCs) from Tarm1–/– mouse bone marrow cells is impaired. We show that type 2 collagen is a functional ligand for TARM1 on GM-DCs and promotes DC maturation. Furthermore, soluble TARM1-Fc and TARM1-Flag inhibit DC maturation and administration of TARM1-Fc blocks the progression of CIA in mice. These results indicate that TARM1 is an important stimulating factor of dendritic cell maturation and could be a good target for the treatment of autoimmune diseases.

Suggested Citation

  • Rikio Yabe & Soo-Hyun Chung & Masanori A. Murayama & Sachiko Kubo & Kenji Shimizu & Yukiko Akahori & Takumi Maruhashi & Akimasa Seno & Tomonori Kaifu & Shinobu Saijo & Yoichiro Iwakura, 2021. "TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20307-9
    DOI: 10.1038/s41467-020-20307-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-20307-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-20307-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20307-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.