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Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells

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  • Lara Ribeiro-Parenti

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
    Service de Chirurgie Générale Œsogastrique et Bariatrique, Hôpital Bichat - Claude-Bernard, Assistance Publique-Hôpitaux de Paris)

  • Anne-Charlotte Jarry

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation)

  • Jean-Baptiste Cavin

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation)

  • Alexandra Willemetz

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation)

  • Johanne Beyec

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
    Sorbonne Université, AP-HP, Hôpital Pitié-Salpêtrière-Charles Foix, Biochimie Endocrinienne et Oncologique)

  • Aurélie Sannier

    (Department of Pathology Bichat Hospital, AP-HP)

  • Samira Benadda

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
    Cell and Tissue Imaging Platform, Inserm, U1149, CNRS, ERL8252)

  • Anne-Laure Pelletier

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation)

  • Muriel Hourseau

    (Department of Pathology Bichat Hospital, AP-HP)

  • Thibaut Léger

    (Université de Paris, Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, CNRS
    Université Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085)

  • Bastien Morlet

    (Université de Paris, Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, CNRS)

  • Anne Couvelard

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
    Department of Pathology Bichat Hospital, AP-HP)

  • Younes Anini

    (Dalhousie University, IWK Health Centre)

  • Simon Msika

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
    Service de Chirurgie Générale Œsogastrique et Bariatrique, Hôpital Bichat - Claude-Bernard, Assistance Publique-Hôpitaux de Paris)

  • Jean-Pierre Marmuse

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
    Service de Chirurgie Générale Œsogastrique et Bariatrique, Hôpital Bichat - Claude-Bernard, Assistance Publique-Hôpitaux de Paris)

  • Sévérine Ledoux

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
    Service des Explorations Fonctionnelles Hôpital Louis Mourier, AP-HP, Centre Intégré Nord Francilien de prise en charge de l’Obésité (CINFO))

  • Maude Gall

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation)

  • André Bado

    (Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation)

Abstract

Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats. In lean rats, a gastric load of glucose induces a rapid and parallel rise in GLP-1 levels in both the gastric and the portal veins. This rise in portal GLP-1 levels was abrogated in HFD obese rats but restored after vertical sleeve gastrectomy (VSG) surgery. Finally, obese rats and individuals operated on Roux-en-Y gastric bypass and SG display a new gastric mucosa phenotype with hyperplasia of the mucus neck cells concomitant with increased density of GLP-1 positive cells. This report brings to light the contribution of gastric GLP-1 expressing cells that undergo plasticity changes after bariatric surgeries, to circulating GLP-1 levels.

Suggested Citation

  • Lara Ribeiro-Parenti & Anne-Charlotte Jarry & Jean-Baptiste Cavin & Alexandra Willemetz & Johanne Beyec & Aurélie Sannier & Samira Benadda & Anne-Laure Pelletier & Muriel Hourseau & Thibaut Léger & Ba, 2021. "Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20301-1
    DOI: 10.1038/s41467-020-20301-1
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    Cited by:

    1. Amit Elad & Botros Moalem & Dana Sender & Aya Bardugo & Ki-Suk Kim & Yhara Arad & Haya Benhayon & Ayelet Gal Etzyoni & Nehemia Greenstein & Aviv Halfon & Sarah Knapp & Michelle Malis & Bailey Peck & I, 2025. "Sleeve gastrectomy reveals the plasticity of the human gastric epithelium," Nature Communications, Nature, vol. 16(1), pages 1-12, December.

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