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Chain-like gold nanoparticle clusters for multimodal photoacoustic microscopy and optical coherence tomography enhanced molecular imaging

Author

Listed:
  • Van Phuc Nguyen

    (University of Michigan
    NTT-Hitech Institutes, Nguyen Tat Thanh University)

  • Wei Qian

    (IMRA America, Inc.)

  • Yanxiu Li

    (University of Michigan)

  • Bing Liu

    (IMRA America, Inc.)

  • Michael Aaberg

    (University of Michigan)

  • Jessica Henry

    (University of Michigan)

  • Wei Zhang

    (University of Michigan)

  • Xueding Wang

    (University of Michigan)

  • Yannis M. Paulus

    (University of Michigan
    University of Michigan)

Abstract

Colloidal gold nanoparticles (GNPs) serve as promising contrast agents in photoacoustic (PA) imaging, yet their utility is limited due to their absorption peak in the visible window overlapping with that of hemoglobin. To overcome such limitation, this report describes an ultrapure chain-like gold nanoparticle (CGNP) clusters with a redshift peak wavelength at 650 nm. The synthesized CGNP show an excellent biocompatibility and photostability. These nanoparticles are conjugated with arginine-glycine-aspartic acid (RGD) peptides (CGNP clusters-RGD) and validated in 12 living rabbits to perform multimodal photoacoustic microscopy (PAM) and optical coherence tomography (OCT) for visualization of newly developed blood vessels in the sub-retinal pigment epithelium (RPE) space of the retina, named choroidal neovascularization (CNV). The PAM system can achieve a 3D PAM image via a raster scan of 256 × 256 pixels within a time duration of 65 s. Intravenous injection of CGNP clusters-RGD bound to CNV and resulted in up to a 17-fold increase in PAM signal and 176% increase in OCT signal. Histology indicates that CGNP clusters could disassemble, which may facilitate its clearance from the body.

Suggested Citation

  • Van Phuc Nguyen & Wei Qian & Yanxiu Li & Bing Liu & Michael Aaberg & Jessica Henry & Wei Zhang & Xueding Wang & Yannis M. Paulus, 2021. "Chain-like gold nanoparticle clusters for multimodal photoacoustic microscopy and optical coherence tomography enhanced molecular imaging," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20276-z
    DOI: 10.1038/s41467-020-20276-z
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