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Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy

Author

Listed:
  • Young Suk Yu

    (Seoul National University)

  • Hijai R. Shin

    (Seoul National University
    University of California Berkeley)

  • Dongha Kim

    (The Catholic University of Korea)

  • Seon Ah Baek

    (Seoul National University)

  • Seon Ah Choi

    (Seoul National University)

  • Hyejin Ahn

    (Seoul National University)

  • Amen Shamim

    (Sungkyunkwan University)

  • Jeonghwan Kim

    (University of Copenhagen
    University of Copenhagen)

  • Ik Soo Kim

    (Seoul National University)

  • Kyeong Kyu Kim

    (Sungkyunkwan University)

  • Kyoung-Jae Won

    (University of Copenhagen
    University of Copenhagen)

  • Sung Hee Baek

    (Seoul National University)

Abstract

Autophagy is a catabolic process through which cytoplasmic components are degraded and recycled in response to various stresses including starvation. Recently, transcriptional and epigenetic regulations of autophagy have emerged as essential mechanisms for maintaining homeostasis. Here, we identify that coactivator-associated arginine methyltransferase 1 (CARM1) methylates Pontin chromatin-remodeling factor under glucose starvation, and methylated Pontin binds Forkhead Box O 3a (FOXO3a). Genome-wide analyses and biochemical studies reveal that methylated Pontin functions as a platform for recruiting Tip60 histone acetyltransferase with increased H4 acetylation and subsequent activation of autophagy genes regulated by FOXO3a. Surprisingly, CARM1-Pontin-FOXO3a signaling axis can work in the distal regions and activate autophagy genes through enhancer activation. Together, our findings provide a signaling axis of CARM1-Pontin-FOXO3a and further expand the role of CARM1 in nuclear regulation of autophagy.

Suggested Citation

  • Young Suk Yu & Hijai R. Shin & Dongha Kim & Seon Ah Baek & Seon Ah Choi & Hyejin Ahn & Amen Shamim & Jeonghwan Kim & Ik Soo Kim & Kyeong Kyu Kim & Kyoung-Jae Won & Sung Hee Baek, 2020. "Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy," Nature Communications, Nature, vol. 11(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-20080-9
    DOI: 10.1038/s41467-020-20080-9
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    Cited by:

    1. Guozhen Gao & Simone Hausmann & Natasha M. Flores & Ana Morales Benitez & Jianjun Shen & Xiaojie Yang & Maria D. Person & Sitaram Gayatri & Donghang Cheng & Yue Lu & Bin Liu & Pawel K. Mazur & Mark T., 2023. "The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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