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Myonuclear content regulates cell size with similar scaling properties in mice and humans

Author

Listed:
  • Kenth-Arne Hansson

    (University of Oslo
    University of Oslo)

  • Einar Eftestøl

    (University of Oslo
    Cincinnati Children’s Hospital Medical Center)

  • Jo C. Bruusgaard

    (University of Oslo
    University of Oslo
    Kristiania University College)

  • Inga Juvkam

    (University of Oslo)

  • Alyssa W. Cramer

    (Cincinnati Children’s Hospital Medical Center)

  • Anders Malthe-Sørenssen

    (University of Oslo
    University of Oslo)

  • Douglas P. Millay

    (Cincinnati Children’s Hospital Medical Center
    University of Cincinnati College of Medicine)

  • Kristian Gundersen

    (University of Oslo)

Abstract

Muscle fibers are the largest cells in the body, and one of its few syncytia. Individual cell sizes are variable and adaptable, but what governs cell size has been unclear. We find that muscle fibers are DNA scarce compared to other cells, and that the nuclear number (N) adheres to the relationship N = aVb where V is the cytoplasmic volume. N invariably scales sublinearly to V (b

Suggested Citation

  • Kenth-Arne Hansson & Einar Eftestøl & Jo C. Bruusgaard & Inga Juvkam & Alyssa W. Cramer & Anders Malthe-Sørenssen & Douglas P. Millay & Kristian Gundersen, 2020. "Myonuclear content regulates cell size with similar scaling properties in mice and humans," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-20057-8
    DOI: 10.1038/s41467-020-20057-8
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    Cited by:

    1. Lance T. Denes & Chase P. Kelley & Eric T. Wang, 2021. "Microtubule-based transport is essential to distribute RNA and nascent protein in skeletal muscle," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    2. Chengyi Sun & Casey O. Swoboda & Fabian Montecino Morales & Cristofer Calvo & Michael J. Petrany & Sreeja Parameswaran & Andrew VonHandorf & Matthew T. Weirauch & Christoph Lepper & Douglas P. Millay, 2024. "Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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