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Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)

Author

Listed:
  • Yubo Wang

    (Hokkaido University)

  • Jose Enrico Q. Quinsaat

    (Hokkaido University)

  • Tomoko Ono

    (Hokkaido University)

  • Masatoshi Maeki

    (Hokkaido University)

  • Manabu Tokeshi

    (Hokkaido University)

  • Takuya Isono

    (Hokkaido University)

  • Kenji Tajima

    (Hokkaido University)

  • Toshifumi Satoh

    (Hokkaido University)

  • Shin-ichiro Sato

    (Hokkaido University)

  • Yutaka Miura

    (The University of Tokyo
    Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology)

  • Takuya Yamamoto

    (Hokkaido University)

Abstract

Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glycol) (c-PEG), having no chemical inhomogeneity, to provide a polymer topology-dependent stabilization for the surface-modification of gold nanoparticles (AuNPs) through physisorption. By simply mixing c-PEG, but not linear counterparts, enables AuNPs to maintain dispersibility through freezing, lyophilization, or heating. Surprisingly, c-PEG endowed AuNPs with even better dispersion stability than thiolated PEG (HS–PEG–OMe). The stronger affinity of c-PEG was confirmed by DLS, ζ-potential, and FT-IR. Furthermore, the c-PEG system exhibited prolonged blood circulation and enhanced tumor accumulation in mice. Our data suggests that c-PEG induces physisorption on AuNPs, supplying sufficient stability toward bio-medical applications, and would be an alternative approach to the gold–sulfur chemisorption.

Suggested Citation

  • Yubo Wang & Jose Enrico Q. Quinsaat & Tomoko Ono & Masatoshi Maeki & Manabu Tokeshi & Takuya Isono & Kenji Tajima & Toshifumi Satoh & Shin-ichiro Sato & Yutaka Miura & Takuya Yamamoto, 2020. "Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19947-8
    DOI: 10.1038/s41467-020-19947-8
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