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Towards a unified open access dataset of molecular interactions

Author

Listed:
  • Pablo Porras

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton)

  • Elisabet Barrera

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton)

  • Alan Bridge

    (SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire)

  • Noemi del-Toro

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton)

  • Gianni Cesareni

    (University of Rome Tor Vergata
    IRCCS Fondazione Santa Lucia)

  • Margaret Duesbury

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton
    UCLA-DOE Institute, University of California)

  • Henning Hermjakob

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton)

  • Marta Iannuccelli

    (University of Rome Tor Vergata)

  • Igor Jurisica

    (Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network
    Departments of Medical Biophysics, and Computer Science, University of Toronto
    Institute of Neuroimmunology, Slovak Academy of Sciences)

  • Max Kotlyar

    (Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network)

  • Luana Licata

    (University of Rome Tor Vergata)

  • Ruth C. Lovering

    (Functional Gene Annotation, Preclinical and Fundamental Science, UCL Institute of Cardiovascular Science, University College London)

  • David J. Lynn

    (Computational and Systems Biology Program, Precision Medicine Theme, South Australian Health and Medical Research Institute
    College of Medicine and Public Health, Flinders University)

  • Birgit Meldal

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton)

  • Bindu Nanduri

    (Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University)

  • Kalpana Paneerselvam

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton)

  • Simona Panni

    (Università della Calabria, Dipartimento di Biologia, Ecologia e Scienze della Terra)

  • Chiara Pastrello

    (Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network)

  • Matteo Pellegrini

    (Department of Molecular, Cell and Developmental Biology, UCLA)

  • Livia Perfetto

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton)

  • Negin Rahimzadeh

    (UCLA-DOE Institute, University of California)

  • Prashansa Ratan

    (UCLA-DOE Institute, University of California)

  • Sylvie Ricard-Blum

    (ICBMS, UMR 5246 University Lyon 1 - CNRS, Univ. Lyon)

  • Lukasz Salwinski

    (UCLA-DOE Institute, University of California)

  • Gautam Shirodkar

    (UCLA-DOE Institute, University of California)

  • Anjalia Shrivastava

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton
    Open Targets, Wellcome Genome Campus, Hinxton)

  • Sandra Orchard

    (European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton)

Abstract

The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources.

Suggested Citation

  • Pablo Porras & Elisabet Barrera & Alan Bridge & Noemi del-Toro & Gianni Cesareni & Margaret Duesbury & Henning Hermjakob & Marta Iannuccelli & Igor Jurisica & Max Kotlyar & Luana Licata & Ruth C. Love, 2020. "Towards a unified open access dataset of molecular interactions," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19942-z
    DOI: 10.1038/s41467-020-19942-z
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