IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-19933-0.html
   My bibliography  Save this article

Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome

Author

Listed:
  • Yeon Hee Park

    (Samsung Medical Center)

  • Samir Lal

    (Oncology Research & Development, Pfizer)

  • Jeong Eon Lee

    (Samsung Medical Center)

  • Yoon-La Choi

    (Samsung Medical Center)

  • Ji Wen

    (Oncology Research & Development, Pfizer)

  • Sripad Ram

    (Drug Safety R&D, Pfizer)

  • Ying Ding

    (Oncology Research & Development, Pfizer)

  • Soo-Hyeon Lee

    (Pfizer Oncology)

  • Eric Powell

    (Oncology Research & Development, Pfizer)

  • Se Kyung Lee

    (Samsung Medical Center)

  • Jong Han Yu

    (Samsung Medical Center)

  • Keith A. Ching

    (Oncology Research & Development, Pfizer)

  • Jae-Yong Nam

    (Samsung Medical Center)

  • Seok Won Kim

    (Samsung Medical Center)

  • Seok Jin Nam

    (Samsung Medical Center)

  • Ji-Yeon Kim

    (Samsung Medical Center)

  • Soo Youn Cho

    (Samsung Medical Center)

  • Seri Park

    (Samsung Medical Center)

  • Jinho Kim

    (Samsung Genome Institute, Samsung Medical Center)

  • Soohyn Hwang

    (Samsung Medical Center)

  • Yu Jin Kim

    (Samsung Medical Center)

  • Vinicius Bonato

    (Biostatistics, Pfizer)

  • Diane Fernandez

    (Oncology Research & Development, Pfizer)

  • Shibing Deng

    (Biostatistics, Pfizer)

  • Shuoguo Wang

    (Oncology Research & Development, Pfizer)

  • Hyuntae Shin

    (Samsung Genome Institute, Samsung Medical Center)

  • Eun-Suk Kang

    (Samsung Medical Center)

  • Woong-Yang Park

    (Samsung Genome Institute, Samsung Medical Center)

  • Paul A. Rejto

    (Oncology Research & Development, Pfizer)

  • Jadwiga Bienkowska

    (Oncology Research & Development, Pfizer)

  • Zhengyan Kan

    (Oncology Research & Development, Pfizer)

Abstract

To elucidate the effects of neoadjuvant chemotherapy (NAC), we conduct whole transcriptome profiling coupled with histopathology analyses of a longitudinal breast cancer cohort of 146 patients including 110 pairs of serial tumor biopsies collected before treatment, after the first cycle of treatment and at the time of surgery. Here, we show that cytotoxic chemotherapies induce dynamic changes in the tumor immune microenvironment that vary by subtype and pathologic response. Just one cycle of treatment induces an immune stimulatory microenvironment harboring more tumor infiltrating lymphocytes (TILs) and up-regulation of inflammatory signatures predictive of response to anti-PD1 therapies while residual tumors are immune suppressed at end-of-treatment compared to the baseline. Increases in TILs and CD8+ T cell proportions in response to NAC are independently associated with pathologic complete response. Further, on-treatment immune response is more predictive of treatment outcome than immune features in paired baseline samples although these are strongly correlated.

Suggested Citation

  • Yeon Hee Park & Samir Lal & Jeong Eon Lee & Yoon-La Choi & Ji Wen & Sripad Ram & Ying Ding & Soo-Hyeon Lee & Eric Powell & Se Kyung Lee & Jong Han Yu & Keith A. Ching & Jae-Yong Nam & Seok Won Kim & S, 2020. "Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19933-0
    DOI: 10.1038/s41467-020-19933-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-19933-0
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-020-19933-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sandra Tietscher & Johanna Wagner & Tobias Anzeneder & Claus Langwieder & Martin Rees & Bettina Sobottka & Natalie Souza & Bernd Bodenmiller, 2023. "A comprehensive single-cell map of T cell exhaustion-associated immune environments in human breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Kang Wang & Ioannis Zerdes & Henrik J. Johansson & Dhifaf Sarhan & Yizhe Sun & Dimitris C. Kanellis & Emmanouil G. Sifakis & Artur Mezheyeuski & Xingrong Liu & Niklas Loman & Ingrid Hedenfalk & Jonas , 2024. "Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-24, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19933-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.