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Rapid de novo evolution of lysis genes in single-stranded RNA phages

Author

Listed:
  • Karthik R. Chamakura

    (Texas A&M University)

  • Jennifer S. Tran

    (Texas A&M University
    University of Wisconsin-Madison)

  • Chandler O’Leary

    (Texas A&M University
    University of North Texas Health Science Center)

  • Hannah G. Lisciandro

    (Texas A&M University)

  • Sophia F. Antillon

    (Texas A&M University)

  • Kameron D. Garza

    (Texas A&M University)

  • Elizabeth Tran

    (Texas A&M University
    University of North Texas Health Science Center)

  • Lorna Min

    (Texas A&M University
    Baylor College of Medicine)

  • Ry Young

    (Texas A&M University)

Abstract

Leviviruses are bacteriophages with small single-stranded RNA genomes consisting of 3-4 genes, one of which (sgl) encodes a protein that induces the host to undergo autolysis and liberate progeny virions. Recent meta-transcriptomic studies have uncovered thousands of leviviral genomes, but most of these lack an annotated sgl, mainly due to the small size, lack of sequence similarity, and embedded nature of these genes. Here, we identify sgl genes in 244 leviviral genomes and functionally characterize them in Escherichia coli. We show that leviviruses readily evolve sgl genes and sometimes have more than one per genome. Moreover, these genes share little to no similarity with each other or to previously known sgl genes, thus representing a rich source for potential protein antibiotics.

Suggested Citation

  • Karthik R. Chamakura & Jennifer S. Tran & Chandler O’Leary & Hannah G. Lisciandro & Sophia F. Antillon & Kameron D. Garza & Elizabeth Tran & Lorna Min & Ry Young, 2020. "Rapid de novo evolution of lysis genes in single-stranded RNA phages," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19860-0
    DOI: 10.1038/s41467-020-19860-0
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    Cited by:

    1. Ran Meng & Zhongliang Xing & Jeng-Yih Chang & Zihao Yu & Jirapat Thongchol & Wen Xiao & Yuhang Wang & Karthik Chamakura & Zhiqi Zeng & Fengbin Wang & Ry Young & Lanying Zeng & Junjie Zhang, 2024. "Structural basis of Acinetobacter type IV pili targeting by an RNA virus," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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