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Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase

Author

Listed:
  • Mark J. Siedner

    (Africa Health Research Institute
    Massachusetts General Hospital
    Harvard Medical School
    University of KwaZulu-Natal)

  • Michelle A. Moorhouse

    (University of Witwatersrand)

  • Bryony Simmons

    (Imperial College)

  • Tulio Oliveira

    (University of KwaZulu-Natal
    KwaZulu-Natal Research Innovation and Sequencing Platform)

  • Richard Lessells

    (University of KwaZulu-Natal
    KwaZulu-Natal Research Innovation and Sequencing Platform)

  • Jennifer Giandhari

    (University of KwaZulu-Natal
    KwaZulu-Natal Research Innovation and Sequencing Platform)

  • Stephen A. Kemp

    (University of Cambridge)

  • Benjamin Chimukangara

    (University of KwaZulu-Natal
    KwaZulu-Natal Research Innovation and Sequencing Platform
    Centre for the AIDS Programme of Research in South Africa (CAPRISA))

  • Godspower Akpomiemie

    (University of Witwatersrand)

  • Celicia M. Serenata

    (University of Witwatersrand)

  • Willem D. F. Venter

    (University of Witwatersrand)

  • Andrew Hill

    (University of Liverpool)

  • Ravindra K. Gupta

    (Africa Health Research Institute
    University of KwaZulu-Natal
    University of Cambridge)

Abstract

Little is known about the impact of pretreatment drug resistance (PDR) on the efficacy of second generation integrase inhibitors. We sequenced pretreatment plasma specimens from the ADVANCE trial (NCT03122262). Our primary outcome was 96-week virologic success, defined as a sustained viral load

Suggested Citation

  • Mark J. Siedner & Michelle A. Moorhouse & Bryony Simmons & Tulio Oliveira & Richard Lessells & Jennifer Giandhari & Stephen A. Kemp & Benjamin Chimukangara & Godspower Akpomiemie & Celicia M. Serenata, 2020. "Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19801-x
    DOI: 10.1038/s41467-020-19801-x
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    Cited by:

    1. Steven A. Kemp & Kimia Kamelian & Diego F. Cuadros & Mark T. K. Cheng & Elphas Okango & Willem Hanekom & Thumbi Ndung’u & Deenan Pillay & David Bonsall & Emily B. Wong & Frank Tanser & Mark J. Siedner, 2024. "HIV transmission dynamics and population-wide drug resistance in rural South Africa," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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