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Building genomes to understand biology

Author

Listed:
  • Alessandro L. V. Coradini

    (University of Southern California)

  • Cara B. Hull

    (University of Southern California)

  • Ian M. Ehrenreich

    (University of Southern California)

Abstract

Genetic manipulation is one of the central strategies that biologists use to investigate the molecular underpinnings of life and its diversity. Thus, advances in genetic manipulation usually lead to a deeper understanding of biological systems. During the last decade, the construction of chromosomes, known as synthetic genomics, has emerged as a novel approach to genetic manipulation. By facilitating complex modifications to chromosome content and structure, synthetic genomics opens new opportunities for studying biology through genetic manipulation. Here, we discuss different classes of genetic manipulation that are enabled by synthetic genomics, as well as biological problems they each can help solve.

Suggested Citation

  • Alessandro L. V. Coradini & Cara B. Hull & Ian M. Ehrenreich, 2020. "Building genomes to understand biology," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19753-2
    DOI: 10.1038/s41467-020-19753-2
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    Cited by:

    1. Abel Brodeur & David Gray & Anik Islam & Suraiya Bhuiyan, 2021. "A literature review of the economics of COVID‐19," Journal of Economic Surveys, Wiley Blackwell, vol. 35(4), pages 1007-1044, September.
    2. Tenbensel, Tim & Cumming, Jacqueline & Willing, Esther, 2023. "The 2022 restructure of Aotearoa New Zealand's health system: Will it succeed in advancing equity where others have failed?," Health Policy, Elsevier, vol. 134(C).
    3. Pradhan, Rudra P. & Arvin, Mak B. & Nair, Mahendhiran S. & Bennett, Sara E., 2023. "Does foreign aid affect innovation and institutional quality in middle-income countries?," Evaluation and Program Planning, Elsevier, vol. 100(C).
    4. Prakash, Navendu & Srivastava, Bhavya & Singh, Shveta & Sharma, Seema & Jain, Sonali, 2022. "Effectiveness of social distancing interventions in containing COVID-19 incidence: International evidence using Kalman filter," Economics & Human Biology, Elsevier, vol. 44(C).
    5. Alessandro L. V. Coradini & Christopher Ne Ville & Zachary A. Krieger & Joshua Roemer & Cara Hull & Shawn Yang & Daniel T. Lusk & Ian M. Ehrenreich, 2023. "Building synthetic chromosomes from natural DNA," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    6. Li, Yufan & Teng, Weichen & Tsai, Limin & Lin, Tom M.Y., 2022. "Does English proficiency support the economic development of non-English-speaking countries? The case of Asia," International Journal of Educational Development, Elsevier, vol. 92(C).
    7. Chang, Shuhua & Li, Anqi & Wang, Xin & Wang, Xinyu, 2022. "Joint optimization of e-commerce supply chain financing strategy and channel contract," European Journal of Operational Research, Elsevier, vol. 303(2), pages 908-927.
    8. Lin Crase, 2021. "Lessons in Policy Incoherence: A Review of Recent Water Policies, Water Planning and Drought Policy in Australia," Economic Papers, The Economic Society of Australia, vol. 40(4), pages 313-330, December.
    9. Li, Shengping & Rismanchi, Behzad & Aye, Lu, 2022. "A simulation-based bottom-up approach for analysing the evolution of residential buildings’ material stocks and environmental impacts – A case study of Inner Melbourne," Applied Energy, Elsevier, vol. 314(C).
    10. Saifur Rahman Chowdhury & Tachlima Chowdhury Sunna & Shakil Ahmed, 2021. "Telemedicine is an important aspect of healthcare services amid COVID‐19 outbreak: Its barriers in Bangladesh and strategies to overcome," International Journal of Health Planning and Management, Wiley Blackwell, vol. 36(1), pages 4-12, January.
    11. Sinha, Shreya & Narain, Nivedita & Bhanjdeo, Arundhita, 2022. "Building back better? Resilience as wellbeing for rural migrant households in Bihar, India," World Development, Elsevier, vol. 159(C).
    12. Chun Zhou & Yun Wang & Yikun Huang & Yongpan An & Xian Fu & Daqian Yang & Yilin Wang & Jintao Zhang & Leslie A. Mitchell & Joel S. Bader & Yizhi Cai & Junbiao Dai & Jef D. Boeke & Zhiming Cai & Zhengw, 2024. "The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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