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Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author

Listed:
  • Valgerdur Steinthorsdottir

    (deCODE genetics/Amgen Inc.)

  • Ralph McGinnis

    (Wellcome Sanger Institute)

  • Nicholas O. Williams

    (Wellcome Sanger Institute)

  • Lilja Stefansdottir

    (deCODE genetics/Amgen Inc.)

  • Gudmar Thorleifsson

    (deCODE genetics/Amgen Inc.)

  • Scott Shooter

    (Wellcome Sanger Institute)

  • João Fadista

    (Statens Serum Institut
    Lund University Diabetes Centre)

  • Jon K. Sigurdsson

    (deCODE genetics/Amgen Inc.)

  • Kirsi M. Auro

    (Finnish Institute for Health and Welfare)

  • Galina Berezina

    (Scientific Center of Obstetrics, Gynecology and Perinatology)

  • Maria-Carolina Borges

    (MRC Integrative Epidemiology Unit, University of Bristol
    Population Health Science, Bristol Medical School, University of Bristol)

  • Suzannah Bumpstead

    (Wellcome Sanger Institute)

  • Jonas Bybjerg-Grauholm

    (Department for Congenital Disorders, Danish Centre for Neonatal Screening, Statens Serum Institut)

  • Irina Colgiu

    (Wellcome Sanger Institute)

  • Vivien A. Dolby

    (Leeds Institute of Medical Research (LIMR), School of Medicine, University of Leeds)

  • Frank Dudbridge

    (London School of Hygiene and Tropical Medicine)

  • Stephanie M. Engel

    (Gillings School of Global Public Health, University of North Carolina at Chapel Hill)

  • Christopher S. Franklin

    (Wellcome Sanger Institute)

  • Michael L. Frigge

    (deCODE genetics/Amgen Inc.)

  • Yr Frisbaek

    (Landspitali University Hospital)

  • Reynir T. Geirsson

    (Landspitali University Hospital)

  • Frank Geller

    (Statens Serum Institut)

  • Solveig Gretarsdottir

    (deCODE genetics/Amgen Inc.)

  • Daniel F. Gudbjartsson

    (deCODE genetics/Amgen Inc.
    University of Iceland)

  • Quaker Harmon

    (Epidemiology Branch, National Institute of Environmental Health Sciences)

  • David Michael Hougaard

    (Department for Congenital Disorders, Danish Centre for Neonatal Screening, Statens Serum Institut)

  • Tatyana Hegay

    (Uzbek Academy of Sciences)

  • Anna Helgadottir

    (deCODE genetics/Amgen Inc.)

  • Sigrun Hjartardottir

    (Landspitali University Hospital)

  • Tiina Jääskeläinen

    (Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital)

  • Hrefna Johannsdottir

    (deCODE genetics/Amgen Inc.)

  • Ingileif Jonsdottir

    (deCODE genetics/Amgen Inc.
    University of Iceland)

  • Thorhildur Juliusdottir

    (deCODE genetics/Amgen Inc.)

  • Noor Kalsheker

    (University of Nottingham)

  • Abdumadjit Kasimov

    (Uzbek Academy of Sciences)

  • John P. Kemp

    (MRC Integrative Epidemiology Unit, University of Bristol
    The University of Queensland)

  • Katja Kivinen

    (University of Cambridge)

  • Kari Klungsøyr

    (Division of Mental and Physical Health, Norwegian Institute of Public Health
    University of Bergen)

  • Wai K. Lee

    (BHF Glasgow Cardiovascular Research Centre, University of Glasgow)

  • Mads Melbye

    (Statens Serum Institut
    University of Copenhagen
    Stanford University School of Medicine)

  • Zosia Miedzybrodska

    (Division of Applied Medicine, School of Medicine, Medical Sciences, Nutrition and Dentistry, University of Aberdeen)

  • Ashley Moffett

    (University of Cambridge)

  • Dilbar Najmutdinova

    (Republic Specialized Scientific Practical Medical Centre of Obstetrics and Gynecology)

  • Firuza Nishanova

    (Republic Specialized Scientific Practical Medical Centre of Obstetrics and Gynecology)

  • Thorunn Olafsdottir

    (deCODE genetics/Amgen Inc.
    University of Iceland)

  • Markus Perola

    (Finnish Institute for Health and Welfare
    Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki)

  • Fiona Broughton Pipkin

    (University of Nottingham)

  • Lucilla Poston

    (King’s College London)

  • Gordon Prescott

    (Division of Applied Medicine, School of Medicine, Medical Sciences, Nutrition and Dentistry, University of Aberdeen
    Lancashire Clinical Trials Unit, University of Central Lancashire)

  • Saedis Saevarsdottir

    (deCODE genetics/Amgen Inc.)

  • Damilya Salimbayeva

    (Scientific Center of Obstetrics, Gynecology and Perinatology)

  • Paula Juliet Scaife

    (University of Nottingham)

  • Line Skotte

    (Statens Serum Institut)

  • Eleonora Staines-Urias

    (London School of Hygiene and Tropical Medicine)

  • Olafur A. Stefansson

    (deCODE genetics/Amgen Inc.)

  • Karina Meden Sørensen

    (The Danish National Biobank, Statens Serum Institut)

  • Liv Cecilie Vestrheim Thomsen

    (University of Bergen
    Norwegian University of Science and Technology (NTNU))

  • Vinicius Tragante

    (deCODE genetics/Amgen Inc.
    Department of Cardiology, University Medical Center Utrecht, University of Utrecht)

  • Lill Trogstad

    (Norwegian Institute of Public Health)

  • Nigel A. B. Simpson

    (Division of Womens and Children’s Health, School of Medicine, University of Leeds)

  • Tamara Aripova

    (Uzbek Academy of Sciences)

  • Juan P. Casas

    (Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System
    Brigham and Women’s Hospital, Harvard Medical School)

  • Anna F. Dominiczak

    (BHF Glasgow Cardiovascular Research Centre, University of Glasgow)

  • James J. Walker

    (Leeds Institute of Medical Research (LIMR), School of Medicine, University of Leeds)

  • Unnur Thorsteinsdottir

    (deCODE genetics/Amgen Inc.
    University of Iceland)

  • Ann-Charlotte Iversen

    (Norwegian University of Science and Technology (NTNU))

  • Bjarke Feenstra

    (Statens Serum Institut)

  • Deborah A. Lawlor

    (MRC Integrative Epidemiology Unit, University of Bristol
    Population Health Science, Bristol Medical School, University of Bristol
    Bristol NIHR Biomedical Research Centre)

  • Heather Allison Boyd

    (Statens Serum Institut)

  • Per Magnus

    (Centre for Fertility and Health, Norwegian Institute of Public Health)

  • Hannele Laivuori

    (Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital
    Helsinki Institute of Life Science, University of Helsinki
    Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology)

  • Nodira Zakhidova

    (Uzbek Academy of Sciences)

  • Gulnara Svyatova

    (Scientific Center of Obstetrics, Gynecology and Perinatology)

  • Kari Stefansson

    (deCODE genetics/Amgen Inc.
    University of Iceland)

  • Linda Morgan

    (University of Nottingham)

Abstract

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.

Suggested Citation

  • Valgerdur Steinthorsdottir & Ralph McGinnis & Nicholas O. Williams & Lilja Stefansdottir & Gudmar Thorleifsson & Scott Shooter & João Fadista & Jon K. Sigurdsson & Kirsi M. Auro & Galina Berezina & Ma, 2020. "Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19733-6
    DOI: 10.1038/s41467-020-19733-6
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    Cited by:

    1. Liang-Dar Hwang & Gabriel Cuellar-Partida & Loic Yengo & Jian Zeng & Jarkko Toivonen & Mikko Arvas & Robin N. Beaumont & Rachel M. Freathy & Gunn-Helen Moen & Nicole M. Warrington & David M. Evans, 2024. "DINGO: increasing the power of locus discovery in maternal and fetal genome-wide association studies of perinatal traits," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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