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Immune suppression in the early stage of COVID-19 disease

Author

Listed:
  • Wenmin Tian

    (Peking University
    Peking University Health Science Center)

  • Nan Zhang

    (Peking University
    Peking University Health Science Center)

  • Ronghua Jin

    (Capital Medical University)

  • Yingmei Feng

    (Capital Medical University)

  • Siyuan Wang

    (Peking University)

  • Shuaixin Gao

    (Peking University)

  • Ruqin Gao

    (Qingdao Municipal Center for Disease Control and Prevention)

  • Guizhen Wu

    (Chinese Center for Disease Control and Prevention (China CDC))

  • Di Tian

    (Capital Medical University)

  • Wenjie Tan

    (Chinese Center for Disease Control and Prevention (China CDC))

  • Yang Chen

    (Peking University
    Peking University Health Science Center)

  • George Fu Gao

    (Chinese Center for Disease Control and Prevention (China CDC)
    Chinese Academy of Sciences)

  • Catherine C. L. Wong

    (Peking University
    Peking University Health Science Center
    Peking University First Hospital
    Peking-Tsinghua Center for Life Sciences)

Abstract

The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and severe types shows that an activated immune response emerges in severely affected patients. We propose a two-stage mechanism of pathogenesis for this unusual viral infection. Our data advance our understanding of the clinical features of COVID-19 infections and provide a resource for future mechanistic and therapeutics studies.

Suggested Citation

  • Wenmin Tian & Nan Zhang & Ronghua Jin & Yingmei Feng & Siyuan Wang & Shuaixin Gao & Ruqin Gao & Guizhen Wu & Di Tian & Wenjie Tan & Yang Chen & George Fu Gao & Catherine C. L. Wong, 2020. "Immune suppression in the early stage of COVID-19 disease," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19706-9
    DOI: 10.1038/s41467-020-19706-9
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    Cited by:

    1. Yanhua Li & Shijie Qin & Lei Dong & Shitong Qiao & Xiao Wang & Dongshan Yu & Pengyue Gao & Yali Hou & Shouzhen Quan & Ying Li & Fengyan Fan & Xin Zhao & Yueyun Ma & George Fu Gao, 2024. "Long-term effects of Omicron BA.2 breakthrough infection on immunity-metabolism balance: a 6-month prospective study," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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