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Genome-enabled discovery of anthraquinone biosynthesis in Senna tora

Author

Listed:
  • Sang-Ho Kang

    (Genomics Division, National Institute of Agricultural Sciences, RDA)

  • Ramesh Prasad Pandey

    (Sun Moon University
    Massachusetts Institute of Technology)

  • Chang-Muk Lee

    (Metabolic Engineering Division, National Institute of Agricultural Sciences, RDA)

  • Joon-Soo Sim

    (Metabolic Engineering Division, National Institute of Agricultural Sciences, RDA)

  • Jin-Tae Jeong

    (National Institute of Horticultural and Herbal Science, RDA)

  • Beom-Soon Choi

    (Phyzen Genomics Institute)

  • Myunghee Jung

    (Seoul National University)

  • Daniel Ginzburg

    (Carnegie Institution for Science)

  • Kangmei Zhao

    (Carnegie Institution for Science)

  • So Youn Won

    (Genomics Division, National Institute of Agricultural Sciences, RDA)

  • Tae-Jin Oh

    (Sun Moon University)

  • Yeisoo Yu

    (Phyzen Genomics Institute
    DNACARE Co. Ltd)

  • Nam-Hoon Kim

    (Phyzen Genomics Institute)

  • Ok Ran Lee

    (Chonnam National University)

  • Tae-Ho Lee

    (Genomics Division, National Institute of Agricultural Sciences, RDA)

  • Puspalata Bashyal

    (Sun Moon University)

  • Tae-Su Kim

    (Sun Moon University)

  • Woo-Haeng Lee

    (Sun Moon University)

  • Charles Hawkins

    (Carnegie Institution for Science)

  • Chang-Kug Kim

    (Genomics Division, National Institute of Agricultural Sciences, RDA)

  • Jung Sun Kim

    (Genomics Division, National Institute of Agricultural Sciences, RDA)

  • Byoung Ohg Ahn

    (Genomics Division, National Institute of Agricultural Sciences, RDA)

  • Seung Yon Rhee

    (Carnegie Institution for Science)

  • Jae Kyung Sohng

    (Sun Moon University)

Abstract

Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible for plant anthraquinone biosynthesis, we reveal the genome sequence of S. tora at the chromosome level with 526 Mb (96%) assembled into 13 chromosomes. Comparison among related plant species shows that a chalcone synthase-like (CHS-L) gene family has lineage-specifically and rapidly expanded in S. tora. Combining genomics, transcriptomics, metabolomics, and biochemistry, we identify a CHS-L gene contributing to the biosynthesis of anthraquinones. The S. tora reference genome will accelerate the discovery of biologically active anthraquinone biosynthesis pathways in medicinal plants.

Suggested Citation

  • Sang-Ho Kang & Ramesh Prasad Pandey & Chang-Muk Lee & Joon-Soo Sim & Jin-Tae Jeong & Beom-Soon Choi & Myunghee Jung & Daniel Ginzburg & Kangmei Zhao & So Youn Won & Tae-Jin Oh & Yeisoo Yu & Nam-Hoon K, 2020. "Genome-enabled discovery of anthraquinone biosynthesis in Senna tora," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19681-1
    DOI: 10.1038/s41467-020-19681-1
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