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Molecular variation in a functionally divergent homolog of FCA regulates flowering time in Arabidopsis thaliana

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  • Yunhe Wang

    (Anhui Agricultural University)

  • Zhen Tao

    (Anhui Agricultural University)

  • Wanyi Wang

    (Anhui Agricultural University)

  • Daniele Filiault

    (Austrian Academy of Sciences, Vienna BioCenter)

  • Chunhong Qiu

    (Anhui Agricultural University)

  • Chuanhong Wang

    (Anhui Agricultural University)

  • Hui Wang

    (Anhui Agricultural University)

  • Shamsur Rehman

    (Anhui Agricultural University)

  • Jian Shi

    (Anhui Agricultural University)

  • Yan Zhang

    (Anhui Agricultural University)

  • Peijin Li

    (Anhui Agricultural University)

Abstract

The identification and functional characterization of natural variants in plants are essential for understanding phenotypic adaptation. Here we identify a molecular variation in At2g47310 that contributes to the natural variation in flowering time in Arabidopsis thaliana accessions. This gene, which we term SISTER of FCA (SSF), functions in an antagonistic manner to its close homolog FCA. Genome-wide association analysis screens two major haplotypes of SSF associated with the natural variation in FLC expression, and a single polymorphism, SSF-N414D, is identified as a main contributor. The SSF414N protein variant interacts more strongly with CUL1, a component of the E3 ubiquitination complex, than the SSF414D form, mediating differences in SSF protein degradation and FLC expression. FCA and SSF appear to have arisen through gene duplication after dicot-monocot divergence, with the SSF-N414D polymorphism emerging relatively recently within A. thaliana. This work provides a good example for deciphering the functional importance of natural polymorphisms in different organisms.

Suggested Citation

  • Yunhe Wang & Zhen Tao & Wanyi Wang & Daniele Filiault & Chunhong Qiu & Chuanhong Wang & Hui Wang & Shamsur Rehman & Jian Shi & Yan Zhang & Peijin Li, 2020. "Molecular variation in a functionally divergent homolog of FCA regulates flowering time in Arabidopsis thaliana," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19666-0
    DOI: 10.1038/s41467-020-19666-0
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    Cited by:

    1. Jing Ma & Shuai Li & Tengyue Wang & Zhen Tao & Shijie Huang & Ning Lin & Yibing Zhao & Chuanhong Wang & Peijin Li, 2025. "Cooperative condensation of RNA-DIRECTED DNA METHYLATION 16 splicing isoforms enhances heat tolerance in Arabidopsis," Nature Communications, Nature, vol. 16(1), pages 1-16, December.

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