Author
Listed:
- Deli Huang
(The Scripps Research Institute)
- Jenny Tuyet Tran
(The Scripps Research Institute)
- Alex Olson
(The Scripps Research Institute)
- Thomas Vollbrecht
(The University of California San Diego)
- Mary Tenuta
(The Scripps Research Institute)
- Mariia V. Guryleva
(Tumor and Cell Biology, Karolinska Institutet
Moscow Lomonosov State University)
- Roberta P. Fuller
(The Scripps Research Institute
The Scripps Research Institute
The Scripps Research Institute)
- Torben Schiffner
(The Scripps Research Institute
The Scripps Research Institute
The Scripps Research Institute)
- Justin R. Abadejos
(The Scripps Research Institute)
- Lauren Couvrette
(The Scripps Research Institute
University of Ottawa)
- Tanya R. Blane
(The Scripps Research Institute)
- Karen Saye
(The Scripps Research Institute
The Scripps Research Institute
The Scripps Research Institute)
- Wenjuan Li
(The Scripps Research Institute)
- Elise Landais
(The Scripps Research Institute
The Scripps Research Institute)
- Alicia Gonzalez-Martin
(Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM))
- William Schief
(The Scripps Research Institute
The Scripps Research Institute
The Scripps Research Institute
Massachusetts Institute of Technology, and Harvard)
- Ben Murrell
(Tumor and Cell Biology, Karolinska Institutet)
- Dennis R. Burton
(The Scripps Research Institute
The Scripps Research Institute
The Scripps Research Institute
Massachusetts Institute of Technology, and Harvard)
- David Nemazee
(The Scripps Research Institute)
- James E. Voss
(The Scripps Research Institute)
Abstract
HIV broadly neutralizing antibodies (bnAbs) can suppress viremia and protect against HIV infection. However, their elicitation is made difficult by low frequencies of appropriate precursor B cell receptors and the complex maturation pathways required to generate bnAbs from these precursors. Antibody genes can be engineered into B cells for expression as both a functional antigen receptor on cell surfaces and as secreted antibody. Here, we show that HIV bnAb-engineered primary mouse B cells can be adoptively transferred and vaccinated in immunocompetent mice resulting in the expansion of durable bnAb memory and long-lived plasma cells. Somatic hypermutation after immunization indicates that engineered cells have the capacity to respond to an evolving pathogen. These results encourage further exploration of engineered B cell vaccines as a strategy for durable elicitation of HIV bnAbs to protect against infection and as a contributor to a functional HIV cure.
Suggested Citation
Deli Huang & Jenny Tuyet Tran & Alex Olson & Thomas Vollbrecht & Mary Tenuta & Mariia V. Guryleva & Roberta P. Fuller & Torben Schiffner & Justin R. Abadejos & Lauren Couvrette & Tanya R. Blane & Kare, 2020.
"Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells,"
Nature Communications, Nature, vol. 11(1), pages 1-10, December.
Handle:
RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19650-8
DOI: 10.1038/s41467-020-19650-8
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