Author
Listed:
- Shidan Tosif
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute
The Royal Children’s Hospital)
- Melanie R. Neeland
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute)
- Philip Sutton
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute)
- Paul V. Licciardi
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute)
- Sohinee Sarkar
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute)
- Kevin J. Selva
(The University of Melbourne)
- Lien Anh Ha Do
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute)
- Celeste Donato
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute)
- Zheng Quan Toh
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute)
- Rachel Higgins
(Infection and Immunity, Murdoch Children’s Research Institute)
- Carolien Van de Sandt
(The University of Melbourne
Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam)
- Melissa M. Lemke
(University of Michigan)
- Christina Y. Lee
(University of Michigan)
- Suzanne K. Shoffner
(University of Michigan)
- Katie L. Flanagan
(Launceston General Hospital
University of Tasmania
Monash University
RMIT University)
- Kelly B. Arnold
(University of Michigan)
- Francesca L. Mordant
(The University of Melbourne)
- Kim Mulholland
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute
Infectious Diseases Unit, Department of General Medicine, The Royal Children’s Hospital)
- Julie Bines
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute
Department of Gastroenterology, The Royal Children’s Hospital)
- Kate Dohle
(Infection and Immunity, Murdoch Children’s Research Institute)
- Daniel G. Pellicci
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute)
- Nigel Curtis
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute
Infectious Diseases Unit, Department of General Medicine, The Royal Children’s Hospital)
- Sarah McNab
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute
The Royal Children’s Hospital)
- Andrew Steer
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute
Infectious Diseases Unit, Department of General Medicine, The Royal Children’s Hospital)
- Richard Saffery
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute)
- Kanta Subbarao
(The University of Melbourne
WHO Collaborating Centre for Reference and Research on Influenza)
- Amy W. Chung
(The University of Melbourne)
- Katherine Kedzierska
(The University of Melbourne)
- David P. Burgner
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute
Infectious Diseases Unit, Department of General Medicine, The Royal Children’s Hospital)
- Nigel W. Crawford
(The University of Melbourne
Infection and Immunity, Murdoch Children’s Research Institute
The Royal Children’s Hospital)
Abstract
Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. Here, we describe clinical features, virology, longitudinal cellular, and cytokine immune profile, SARS-CoV-2-specific serology and salivary antibody responses in a family of two parents with PCR-confirmed symptomatic SARS-CoV-2 infection and their three children, who tested repeatedly SARS-CoV-2 PCR negative. Cellular immune profiles and cytokine responses of all children are similar to their parents at all timepoints. All family members have salivary anti-SARS-CoV-2 antibodies detected, predominantly IgA, that coincide with symptom resolution in 3 of 4 symptomatic members. Plasma from both parents and one child have IgG antibody against the S1 protein and virus-neutralizing activity detected. Using a systems serology approach, we demonstrate higher levels of SARS-CoV-2-specific antibody features of these family members compared to healthy controls. These data indicate that children can mount an immune response to SARS-CoV-2 without virological confirmation of infection, raising the possibility that immunity in children can prevent the establishment of SARS-CoV-2 infection. Relying on routine virological and serological testing may not identify exposed children, with implications for epidemiological and clinical studies across the life-span.
Suggested Citation
Shidan Tosif & Melanie R. Neeland & Philip Sutton & Paul V. Licciardi & Sohinee Sarkar & Kevin J. Selva & Lien Anh Ha Do & Celeste Donato & Zheng Quan Toh & Rachel Higgins & Carolien Van de Sandt & Me, 2020.
"Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19,"
Nature Communications, Nature, vol. 11(1), pages 1-8, December.
Handle:
RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19545-8
DOI: 10.1038/s41467-020-19545-8
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