IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-19381-w.html
   My bibliography  Save this article

A circular RNA generated from an intron of the insulin gene controls insulin secretion

Author

Listed:
  • Lisa Stoll

    (University of Lausanne
    Department of Medicine, Weill Cornell Medicine)

  • Adriana Rodríguez-Trejo

    (University of Lausanne)

  • Claudiane Guay

    (University of Lausanne)

  • Flora Brozzi

    (University of Lausanne)

  • Mustafa Bilal Bayazit

    (University of Lausanne)

  • Sonia Gattesco

    (University of Lausanne)

  • Véronique Menoud

    (University of Lausanne)

  • Jonathan Sobel

    (University of Lausanne)

  • Ana Claudia Marques

    (University of Lausanne)

  • Morten Trillingsgaard Venø

    (Aarhus University)

  • Jonathan Lou S. Esguerra

    (Lund University)

  • Mohammad Barghouth

    (Lund University)

  • Mara Suleiman

    (University of Pisa)

  • Lorella Marselli

    (University of Pisa)

  • Jørgen Kjems

    (Aarhus University)

  • Lena Eliasson

    (Lund University)

  • Erik Renström

    (Lund University)

  • Karim Bouzakri

    (UMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg)

  • Michel Pinget

    (UMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg)

  • Piero Marchetti

    (University of Pisa)

  • Romano Regazzi

    (University of Lausanne
    University of Lausanne)

Abstract

Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose homeostasis. Here, we report that insulin secretion is regulated by a circular RNA containing the lariat sequence of the second intron of the insulin gene. Silencing of this intronic circular RNA in pancreatic islets leads to a decrease in the expression of key components of the secretory machinery of β-cells, resulting in impaired glucose- or KCl-induced insulin release and calcium signaling. The effect of the circular RNA is exerted at the transcriptional level and involves an interaction with the RNA-binding protein TAR DNA-binding protein 43 kDa (TDP-43). The level of this circularized intron is reduced in the islets of rodent diabetes models and of type 2 diabetic patients, possibly explaining their impaired secretory capacity. The study of this and other circular RNAs helps understanding β-cell dysfunction under diabetes conditions, and the etiology of this common metabolic disorder.

Suggested Citation

  • Lisa Stoll & Adriana Rodríguez-Trejo & Claudiane Guay & Flora Brozzi & Mustafa Bilal Bayazit & Sonia Gattesco & Véronique Menoud & Jonathan Sobel & Ana Claudia Marques & Morten Trillingsgaard Venø & J, 2020. "A circular RNA generated from an intron of the insulin gene controls insulin secretion," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19381-w
    DOI: 10.1038/s41467-020-19381-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-19381-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-19381-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yue Liu & Yue Yang & Chenying Xu & Jianxing Liu & Jiale Chen & Guoqing Li & Bin Huang & Yi Pan & Yanfeng Zhang & Qiong Wei & Stephen J. Pandol & Fangfang Zhang & Ling Li & Liang Jin, 2023. "Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19381-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.