IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-19346-z.html
   My bibliography  Save this article

Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread

Author

Listed:
  • Gage K. Moreno

    (University of Wisconsin-Madison)

  • Katarina M. Braun

    (University of Wisconsin-Madison)

  • Kasen K. Riemersma

    (University of Wisconsin-Madison)

  • Michael A. Martin

    (Emory University
    Emory University)

  • Peter J. Halfmann

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • Chelsea M. Crooks

    (University of Wisconsin-Madison)

  • Trent Prall

    (University of Wisconsin-Madison)

  • David Baker

    (University of Wisconsin-Madison)

  • John J. Baczenas

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • Anna S. Heffron

    (University of Wisconsin-Madison)

  • Mitchell Ramuta

    (University of Wisconsin-Madison)

  • Manjeet Khubbar

    (City of Milwaukee Health Department Laboratory)

  • Andrea M. Weiler

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • Molly A. Accola

    (University of Wisconsin School of Medicine and Public Health
    The William S. Middleton Memorial Veterans Hospital)

  • William M. Rehrauer

    (University of Wisconsin School of Medicine and Public Health
    The William S. Middleton Memorial Veterans Hospital)

  • Shelby L. O’Connor

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • Nasia Safdar

    (University of Wisconsin School of Medicine and Public Health)

  • Caitlin S. Pepperell

    (University of Wisconsin School of Medicine and Public Health
    University of Wisconsin-Madison)

  • Trivikram Dasu

    (City of Milwaukee Health Department Laboratory)

  • Sanjib Bhattacharyya

    (City of Milwaukee Health Department Laboratory)

  • Yoshihiro Kawaoka

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • Katia Koelle

    (Emory University)

  • David H. O’Connor

    (University of Wisconsin-Madison)

  • Thomas C. Friedrich

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

Abstract

Evidence-based public health approaches that minimize the introduction and spread of new SARS-CoV-2 transmission clusters are urgently needed in the United States and other countries struggling with expanding epidemics. Here we analyze 247 full-genome SARS-CoV-2 sequences from two nearby communities in Wisconsin, USA, and find surprisingly distinct patterns of viral spread. Dane County had the 12th known introduction of SARS-CoV-2 in the United States, but this did not lead to descendant community spread. Instead, the Dane County outbreak was seeded by multiple later introductions, followed by limited community spread. In contrast, relatively few introductions in Milwaukee County led to extensive community spread. We present evidence for reduced viral spread in both counties following the statewide “Safer at Home” order, which went into effect 25 March 2020. Our results suggest patterns of SARS-CoV-2 transmission may vary substantially even in nearby communities. Understanding these local patterns will enable better targeting of public health interventions.

Suggested Citation

  • Gage K. Moreno & Katarina M. Braun & Kasen K. Riemersma & Michael A. Martin & Peter J. Halfmann & Chelsea M. Crooks & Trent Prall & David Baker & John J. Baczenas & Anna S. Heffron & Mitchell Ramuta &, 2020. "Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19346-z
    DOI: 10.1038/s41467-020-19346-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-19346-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-19346-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19346-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.