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Eosinophils improve cardiac function after myocardial infarction

Author

Listed:
  • Jing Liu

    (Brigham and Women’s Hospital and Harvard Medical School
    Huazhong University of Science and Technology)

  • Chongzhe Yang

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Tianxiao Liu

    (Brigham and Women’s Hospital and Harvard Medical School
    Huazhong University of Science and Technology)

  • Zhiyong Deng

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Wenqian Fang

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Xian Zhang

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Jie Li

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Qin Huang

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Conglin Liu

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Yunzhe Wang

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Dafeng Yang

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Galina K. Sukhova

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Jes S. Lindholt

    (Odense University Hospital
    Odense University Hospital
    Cardiovascular Research Unit, Viborg Hospital)

  • Axel Diederichsen

    (Odense University Hospital
    Odense University Hospital)

  • Lars M. Rasmussen

    (Odense University Hospital
    Odense University Hospital)

  • Dazhu Li

    (Huazhong University of Science and Technology)

  • Gail Newton

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Francis W. Luscinskas

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Lijun Liu

    (University of Toledo)

  • Peter Libby

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Jing Wang

    (Peking Union Medical College)

  • Junli Guo

    (Brigham and Women’s Hospital and Harvard Medical School
    Hainan Medical University)

  • Guo-Ping Shi

    (Brigham and Women’s Hospital and Harvard Medical School)

Abstract

Clinical studies reveal changes in blood eosinophil counts and eosinophil cationic proteins that may serve as risk factors for human coronary heart diseases. Here we report an increase of blood or heart eosinophil counts in humans and mice after myocardial infarction (MI), mostly in the infarct region. Genetic or inducible depletion of eosinophils exacerbates cardiac dysfunction, cell death, and fibrosis post-MI, with concurrent acute increase of heart and chronic increase of splenic neutrophils and monocytes. Mechanistic studies reveal roles of eosinophil IL4 and cationic protein mEar1 in blocking H2O2- and hypoxia-induced mouse and human cardiomyocyte death, TGF-β-induced cardiac fibroblast Smad2/3 activation, and TNF-α-induced neutrophil adhesion on the heart endothelial cell monolayer. In vitro-cultured eosinophils from WT mice or recombinant mEar1 protein, but not eosinophils from IL4-deficient mice, effectively correct exacerbated cardiac dysfunctions in eosinophil-deficient ∆dblGATA mice. This study establishes a cardioprotective role of eosinophils in post-MI hearts.

Suggested Citation

  • Jing Liu & Chongzhe Yang & Tianxiao Liu & Zhiyong Deng & Wenqian Fang & Xian Zhang & Jie Li & Qin Huang & Conglin Liu & Yunzhe Wang & Dafeng Yang & Galina K. Sukhova & Jes S. Lindholt & Axel Diederich, 2020. "Eosinophils improve cardiac function after myocardial infarction," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19297-5
    DOI: 10.1038/s41467-020-19297-5
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