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A role of oligodendrocytes in information processing

Author

Listed:
  • Sharlen Moore

    (Max Planck Institute of Experimental Medicine
    International Max Planck Research School for Neurosciences
    Georg-August-Universität Göttingen
    Johns Hopkins University)

  • Martin Meschkat

    (Max Planck Institute of Experimental Medicine
    Center for Nanoscale Microscopy and Molecular Physiology of the Brain)

  • Torben Ruhwedel

    (Max Planck Institute of Experimental Medicine)

  • Andrea Trevisiol

    (Max Planck Institute of Experimental Medicine
    Sunnybrook Health Sciences Centre)

  • Iva D. Tzvetanova

    (Max Planck Institute of Experimental Medicine
    European University Cyprus)

  • Arne Battefeld

    (Netherlands Institute for Neurosciences, Royal Netherlands Academy of Arts and Science
    Université de Bordeaux)

  • Kathrin Kusch

    (Max Planck Institute of Experimental Medicine)

  • Maarten H. P. Kole

    (Netherlands Institute for Neurosciences, Royal Netherlands Academy of Arts and Science
    University of Utrecht)

  • Nicola Strenzke

    (University Medical Center)

  • Wiebke Möbius

    (Max Planck Institute of Experimental Medicine
    Center for Nanoscale Microscopy and Molecular Physiology of the Brain)

  • Livia de Hoz

    (Max Planck Institute of Experimental Medicine
    Charité Medical University, Neuroscience Research Center)

  • Klaus-Armin Nave

    (Max Planck Institute of Experimental Medicine
    Center for Nanoscale Microscopy and Molecular Physiology of the Brain)

Abstract

Myelinating oligodendrocytes enable fast propagation of action potentials along the ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including axonal metabolic support and activity-dependent myelination. An open question remains whether myelination also contributes to information processing in addition to speeding up conduction velocity. Here, we analyze the role of myelin in auditory information processing using paradigms that are also good predictors of speech understanding in humans. We compare mice with different degrees of dysmyelination using acute multiunit recordings in the auditory cortex, in combination with behavioral readouts. We find complex alterations of neuronal responses that reflect fatigue and temporal acuity deficits. We observe partially discriminable but similar deficits in well myelinated mice in which glial cells cannot fully support axons metabolically. We suggest a model in which myelination contributes to sustained stimulus perception in temporally complex paradigms, with a role of metabolically active oligodendrocytes in cortical information processing.

Suggested Citation

  • Sharlen Moore & Martin Meschkat & Torben Ruhwedel & Andrea Trevisiol & Iva D. Tzvetanova & Arne Battefeld & Kathrin Kusch & Maarten H. P. Kole & Nicola Strenzke & Wiebke Möbius & Livia de Hoz & Klaus-, 2020. "A role of oligodendrocytes in information processing," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19152-7
    DOI: 10.1038/s41467-020-19152-7
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    Cited by:

    1. Frederic Fiore & Khaleel Alhalaseh & Ram R. Dereddi & Felipe Bodaleo Torres & Ilknur Çoban & Ali Harb & Amit Agarwal, 2023. "Norepinephrine regulates calcium signals and fate of oligodendrocyte precursor cells in the mouse cerebral cortex," Nature Communications, Nature, vol. 14(1), pages 1-25, December.

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