IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-19146-5.html
   My bibliography  Save this article

Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein

Author

Listed:
  • Antoni G. Wrobel

    (Francis Crick Institute)

  • Donald J. Benton

    (Francis Crick Institute)

  • Saira Hussain

    (Francis Crick Institute)

  • Ruth Harvey

    (Francis Crick Institute)

  • Stephen R. Martin

    (Francis Crick Institute)

  • Chloë Roustan

    (Francis Crick Institute)

  • Peter B. Rosenthal

    (Francis Crick Institute)

  • John J. Skehel

    (Francis Crick Institute)

  • Steven J. Gamblin

    (Francis Crick Institute)

Abstract

The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.

Suggested Citation

  • Antoni G. Wrobel & Donald J. Benton & Saira Hussain & Ruth Harvey & Stephen R. Martin & Chloë Roustan & Peter B. Rosenthal & John J. Skehel & Steven J. Gamblin, 2020. "Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein," Nature Communications, Nature, vol. 11(1), pages 1-5, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19146-5
    DOI: 10.1038/s41467-020-19146-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-19146-5
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-020-19146-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. David Hueting & Karen Schriever & Rui Sun & Stelios Vlachiotis & Fanglei Zuo & Likun Du & Helena Persson & Camilla Hofström & Mats Ohlin & Karin Walldén & Marcus Buggert & Lennart Hammarström & Harold, 2023. "Design, structure and plasma binding of ancestral β-CoV scaffold antigens," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Oskar Staufer & Kapil Gupta & Jochen Estebano Hernandez Bücher & Fabian Kohler & Christian Sigl & Gunjita Singh & Kate Vasileiou & Ana Yagüe Relimpio & Meline Macher & Sebastian Fabritz & Hendrik Diet, 2022. "Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Andrew C. Hunt & Bastian Vögeli & Ahmed O. Hassan & Laura Guerrero & Weston Kightlinger & Danielle J. Yoesep & Antje Krüger & Madison DeWinter & Michael S. Diamond & Ashty S. Karim & Michael C. Jewett, 2023. "A rapid cell-free expression and screening platform for antibody discovery," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19146-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.